Controlled clinical study of skeletal ischemia reperfusion injury in chronic arterial occlusive disease

doi:10.3877/cma.j.issn.1674-0793.2009.04.009

Abstract

Abstract:

Objective

To study responses of skeletal in patients with chronic arterial occlusive disease(CAOD)to ischemia reperfusion injury.

Methods

Twenty-three patients with CAOD awaiting bypass operation were observed as research group.Thirty-one patients undergoing elective open repair of an infrarenal abdominal aortic aneurysm (AAA)were observed as control group.Clamping and declamping arterial for anastomoses were served as ischemia reperfusion injury(IRI).LDH,CK,MB as indicators of skeletal injury before operation and first 3 days after operation were detected.

Results

Excepting LDH did not differ significantly at postoperation day 3,other indicators in CAOD were lower significantly than in AAA (P<0.01).

Conclusion

Similar to ischemic preconditioning,skeletal in patients with CAOD has much more tolerance to IRI in operation.

Key words: Chronic arterial occlusive disease, Skeletal, Ischemia reperifusion injury

Ying-bin JIA, Xiao-dong GUAN, Yong-hui SU, Jian LI, Bai-meng ZHANG. Controlled clinical study of skeletal ischemia reperfusion injury in chronic arterial occlusive disease[J]. Chinese Archives of General Surgery(Electronic Edition), 2009, 03(04): 296-298.

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URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2009.04.009

https://zhptwkxwx.cma-cmc.com.cn/EN/Y2009/V03/I04/296

Figures/Tables 1

References 7

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	对照组（31例）			试验组（23例）
	乳酸脱氢酶（U/L）	肌酸激酶（U/L）	肌红蛋白（μg/L）	乳酸脱氢酶（U/L）	肌酸激酶（U/L）	肌红蛋白（μg/L）
术前	116±8	97±43	123±26	124±6	104±18	130±23
术后
1d	139±5	735±153	792±110	125±3^*	260±23^*	310±63^*
2d	189±15	1790±420	655±143	141±11^*	420±46^*	175±32^*
3d	155±6	1360±302	332±72	161±16	296±32^*	126±18^*

	对照组（31例）			试验组（23例）
	乳酸脱氢酶（U/L）	肌酸激酶（U/L）	肌红蛋白（μg/L）	乳酸脱氢酶（U/L）	肌酸激酶（U/L）	肌红蛋白（μg/L）
术前	116±8	97±43	123±26	124±6	104±18	130±23
术后
1d	139±5	735±153	792±110	125±3^*	260±23^*	310±63^*
2d	189±15	1790±420	655±143	141±11^*	420±46^*	175±32^*
3d	155±6	1360±302	332±72	161±16	296±32^*	126±18^*

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