Abstract:
Objective To investigate the safety and feasibility of immunosuppressive regimen with steroids 24 hours withdrawal in liver transplantation.
Methods Seventy-six patients in line with the selecting criteria were divided into two groups according to the withdrawal of steroids: 40 cases in 3 months withdrawal group and the other 36 cases in 24 hours withdrawal group. The difference of recipients’ survival, infection, acute rejection, wound healing, recurrence of hepatitis B virus (HBV) and hepatocellular carcinoma (HCC), new on-set of diabetes, hyperlipoidemia and hypertension between the two groups were compared.
Results The difference of recipients’ survival, acute rejection including steroids resistant acute rejection, recurrence of HBV and HCC, hyperlipoidemia between the two groups were not significant. Incidence of infection, new on-set diabetes, wound unhealing and hypertension in 24 h withdrawal group was significantly lower than that in 3 months withdrawal group.
Conclusion Steroids 24 hours withdrawal immunosuppressive strategy is safe and feasible in liver transplantation field, it will significantly reduce the steroids related complications.
Key words:
Liver transplantation,
Immunosuppressant,
Steroid,
Withdrawal,
Side effect
Lin-wei WU, Xiao-shun HE, Zhi-yong GUO, Qiang TAI, Wei-qiang JU, Dong-ping WANG, Xiao-feng ZHU, Yi MA, Guo-dong WANG, An-bin HU. Safety of immunosuppressive regimen with steroids twenty-four hours withdrawal in liver transplantation[J]. Chinese Archives of General Surgery(Electronic Edition), 2011, 05(02): 133-136.