Study of relation between nodular goiter and thyroid cancer

doi:10.3877/cma.j.issn.1674-0793.2011.02.012

Abstract

Abstract:

Objective

To study the relation between nodular goiter and thyroid cancer.

Methods

Immunohistochemical method was used to detect expression of p27 protein in 58 cases of nodular goiter, 15 cases of nodular goiter with hyperplastic nodule, 44 cases of thyroid cancer and 20 cases of normal thyroid tissue.

Results

The positive expression rate of p27 protein was 60.5% in normal thyroid tissue, 38.6% in nodular goiter, 34.1% in thyroid cancer and 0 in nodular goiter with hyperplastic nodule. The positive expression rate of p27 protein in both nodular goiter and thyroid cancer was significantly higher than this in nodular goiter with hyperplastic nodule (P<0.01).

Conclusions

Nodular goiter with hyperplastic nodule may be a premalignant lesion, nodular goiter had malignant potential.

Key words: Nodular goiter, Hyperplastic nodule, Thyroid cancer, p27 protein

Chi-zhuai LIU, Tian-xiong SHI, Jian-wei DENG, Shi-jun SUN, Bing-xing ZHENG, Juan DU. Study of relation between nodular goiter and thyroid cancer[J]. Chinese Archives of General Surgery(Electronic Edition), 2011, 05(02): 137-139.

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URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2011.02.012

https://zhptwkxwx.cma-cmc.com.cn/EN/Y2011/V05/I02/137

Figures/Tables 5

References 9

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组别	例数	阳性表达
组别	例数	例数	百分比
对照组	20	13	60.5
结节性甲状腺肿	58	22	38.6^△*
结节性甲状腺肿伴增生结节	15	0	0^△
甲状腺癌	44	15	34.1^△*

组别	例数	阳性表达
组别	例数	例数	百分比
对照组	20	13	60.5
结节性甲状腺肿	58	22	38.6^△*
结节性甲状腺肿伴增生结节	15	0	0^△
甲状腺癌	44	15	34.1^△*

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