Clinical features of Hashimoto’s thyroiditis complicated with thyroid carcinoma

doi:10.3877/cma.j.issn.1674-0793.2011.05.010

Abstract

Abstract:

Objective

To analyze the imaging appearance and pathologic diagnosis in patients with Hashimoto’s thyroiditis (HT) complicated with thyroid carcinoma (TC) and to explore the diagnosis and surgical treatment.

Methods

The clinical and pathological data of patients with HT complicated with thyroid carcinoma were reviewed retrospectively. The preoperative US characteristics and postoperative histopathologic features in patients with and without HT were compared.

Results

The prevalence of TC in the HT patients was 27.0%. In contrast, it was 13.0% in patients without HT (P < 0.01) . The US characteristics of thyroid carcinoma were similar in the group with HT compared with the group without HT. The histopathologic characteristics of thyroid carcinoma in patients with and without HT were compared, there was no significant difference. All patients received surgical treatment. Twenty three patients underwent routine follow-up, and they had no recurrence or metastasis.

Conclusions

Nodules in patients with HT goiter need close observation of neoplastic changes because HT may predispose to the development of TC. Surgical treatment is effective for patients of HT complicated with TC is effective, and the measures of treatment may be in accordance with the principle of TC without HT.

Key words: Hashimoto’s thyroiditis, Thyroid carcinoma, Surgical treatment

Xi LI, Wei-ping GUO, Wan-shou QIU, Tu-feng CHEN. Clinical features of Hashimoto’s thyroiditis complicated with thyroid carcinoma[J]. Chinese Archives of General Surgery(Electronic Edition), 2011, 05(05): 402-405.

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Figures/Tables 2

References 13

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超声改变	合并HT（24例）	不合并HT（190例）	P值
等回声或高回声	4（16.7）	45（23.7）	0.441
低回声	20（83.4）	145（76.3）	?
实性肿物	22（91.7）	187（96.3）	0.267
混合性肿物	2（8.3）	7（3.7）	?
有恶性钙化	11（45.8）	90（47.4）	0.380
无声晕	21（87.5）	170（90.5）	0.427
边界不规则	18（75.0）	166（87.4）	0.096
多发肿物	17（79.2）	135（65.8）	0.404

超声改变	合并HT（24例）	不合并HT（190例）	P值
等回声或高回声	4（16.7）	45（23.7）	0.441
低回声	20（83.4）	145（76.3）	?
实性肿物	22（91.7）	187（96.3）	0.267
混合性肿物	2（8.3）	7（3.7）	?
有恶性钙化	11（45.8）	90（47.4）	0.380
无声晕	21（87.5）	170（90.5）	0.427
边界不规则	18（75.0）	166（87.4）	0.096
多发肿物	17（79.2）	135（65.8）	0.404

病理改变	合并HT组（24例）	不合并HT组（190例）	P值
包膜侵犯	7（29.1）	80（42.1）	0.224
微小癌	6（25.0）	35（18.4）	0.440
甲状腺外侵犯	2（8.3）	29（15.3）	0.288
多灶性肿瘤	5（20.8）	37（19.5）	0.481
淋巴转移	7（29.2）	75（39.5）	0.328

病理改变	合并HT组（24例）	不合并HT组（190例）	P值
包膜侵犯	7（29.1）	80（42.1）	0.224
微小癌	6（25.0）	35（18.4）	0.440
甲状腺外侵犯	2（8.3）	29（15.3）	0.288
多灶性肿瘤	5（20.8）	37（19.5）	0.481
淋巴转移	7（29.2）	75（39.5）	0.328

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