A 12-year study of bloodstream infection after liver transplantation: microbial epidemiology and clinical outcome of extended-spectrum β-lactamases (ESBLs) -producing Klebsiella spp and Escherichia coli

doi:10.3877/cma.j.issn.1674-0793.2011.05.015

Abstract

Abstract:

Objective

To define the microbial epidemiology and outcome of Extended-spectrum β-lactamases (ESBLs) -producing Klebsiella spp. and Escherichia coli in bloodstream infections (BSI) after liver transplantation.

Methods

From January 1998 to December 2009, a retrospective analysis of ESBLs-producing Klebsiella spp. and Escherichia coli were conducted.

Results

BSI occurred in 19 (2.5%) patients of the 768 patients, in which a total 23 gram-negative bacilli (GNB) were isolated. The most frequent pathogens were Escherichia coli and Klebsiella spp. enterobacter cloacae, pseudomonas aeruginosa, Enterobacter aerogenes were few. Carbapenems were the most consistently active against the Escherichia coli and Klebsiella spp which were resistant to ceftriaxone. No significance in 15-day, 30-day, 1-year mortality between ESBL-producing and non-ESBL-producing Klebsiella spp. and Esche-richia coli.

Conclusion

ESBL-producing Klebsiella spp. and Escherichia coli after liver transplantion are resistant to agents but active to Carbapenems commonly, which can not increase 15-day, 30-day, 1-year mortality simultneously.

Key words: Escherichia coli, Klebsiella pneumoniae, Epidemiology, Bacteriology, Extended-spectrum β-lactamases, Susceptibility, Mortality

Qiang TAI, Xiao-shun HE, Kang LIAO, Lin-wei WU, Wei-qiang JU, Xiao-feng ZHU, Yi MA, Dong-ping WANG, Guo-dong WANG, Zhi-yong GUO, Jie-fu HUANG. A 12-year study of bloodstream infection after liver transplantation: microbial epidemiology and clinical outcome of extended-spectrum β-lactamases (ESBLs) -producing Klebsiella spp and Escherichia coli[J]. Chinese Archives of General Surgery(Electronic Edition), 2011, 05(05): 421-424.

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URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2011.05.015

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References 11

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敏感率（%）	厄他培南	亚胺培南	美罗培南	头孢曲松	头孢他啶	头孢西丁	头孢吡肟
大肠埃希菌（15株）	100	100	100	6.7	60	88.9	33.3
肺炎克雷伯菌（5株）	-	100	100	0	60	40	20
敏感率（%）	哌拉西林/他唑巴坦	阿米卡星	妥布霉素	环丙沙星	左旋氧氟沙星	头孢哌酮/舒巴坦	庆大霉素
大肠埃希菌（15株）	73.3	93.3	16.7	33.3	0	-	26.7
肺炎克雷伯菌（5株）	20	40	-	20	-	20	40

敏感率（%）	厄他培南	亚胺培南	美罗培南	头孢曲松	头孢他啶	头孢西丁	头孢吡肟
大肠埃希菌（15株）	100	100	100	6.7	60	88.9	33.3
肺炎克雷伯菌（5株）	-	100	100	0	60	40	20
敏感率（%）	哌拉西林/他唑巴坦	阿米卡星	妥布霉素	环丙沙星	左旋氧氟沙星	头孢哌酮/舒巴坦	庆大霉素
大肠埃希菌（15株）	73.3	93.3	16.7	33.3	0	-	26.7
肺炎克雷伯菌（5株）	20	40	-	20	-	20	40

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