A 12-year study of bloodstream infection after liver transplantation: microbial epidemiology and clinical outcome of extended-spectrum &#x03B2;-lactamases (ESBLs) -producing Klebsiella spp and Escherichia coli

doi:10.3877/cma.j.issn.1674-0793.2011.05.015

Abstract

Abstract:

Objective

To define the microbial epidemiology and outcome of Extended-spectrum β-lactamases (ESBLs) -producing Klebsiella spp. and Escherichia coli in bloodstream infections (BSI) after liver transplantation.

Methods

From January 1998 to December 2009, a retrospective analysis of ESBLs-producing Klebsiella spp. and Escherichia coli were conducted.

Results

BSI occurred in 19 (2.5%) patients of the 768 patients, in which a total 23 gram-negative bacilli (GNB) were isolated. The most frequent pathogens were Escherichia coli and Klebsiella spp. enterobacter cloacae, pseudomonas aeruginosa, Enterobacter aerogenes were few. Carbapenems were the most consistently active against the Escherichia coli and Klebsiella spp which were resistant to ceftriaxone. No significance in 15-day, 30-day, 1-year mortality between ESBL-producing and non-ESBL-producing Klebsiella spp. and Esche-richia coli.

Conclusion

ESBL-producing Klebsiella spp. and Escherichia coli after liver transplantion are resistant to agents but active to Carbapenems commonly, which can not increase 15-day, 30-day, 1-year mortality simultneously.

Key words: Escherichia coli, Klebsiella pneumoniae, Epidemiology, Bacteriology, Extended-spectrum β-lactamases, Susceptibility, Mortality

Qiang TAI, Xiao-shun HE, Kang LIAO, Lin-wei WU, Wei-qiang JU, Xiao-feng ZHU, Yi MA, Dong-ping WANG, Guo-dong WANG, Zhi-yong GUO, Jie-fu HUANG. A 12-year study of bloodstream infection after liver transplantation: microbial epidemiology and clinical outcome of extended-spectrum β-lactamases (ESBLs) -producing Klebsiella spp and Escherichia coli[J]. Chinese Archives of General Surgery(Electronic Edition), 2011, 05(05): 421-424.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2011.05.015

https://zhptwkxwx.cma-cmc.com.cn/EN/Y2011/V05/I05/421

Figures/Tables 1

References 11

1	Bert F，Larroque B，Paugam-Burtz，et al. Microbial epidemiology and outcome of bloodstream infections in liver transplant recipients：An analysis of 259 episodes. Liver transpl，2010，16(3):393-401.
2	Melzer M，Petersen I. Mortality following bacteraemic infection caused by extended spectrum beta-lactamase（ESBL）producing E. coli compared to non-ESBL producing E. coli. J Infect，2007，55(3):254-259.
3	Schwaber MJ，Cosgrove SE，Gold HS，et al. Fluoroquinolones protective against cephalosporin resistance in gram-negative nosocomial pathogens. Emerg Infect Dis，2004，10(1):94-99.
4	Pfaller MA，Segreti J. Overview of the epidemiological profile and laboratory detection of extended-spectrum beta-lactamases. Clin Infect Dis，2006，42(S4):S153-S163.
5	杨银梅，叶惠芬，陈惠玲，等. 广州地区1998~2003年大肠埃希氏和肺炎克雷伯菌耐药性监测. 中国误诊学杂志，2006，6(18):3498-3500.
6	Kaye KS，Cosgrove S，Harris A，et al. Risk factors for emergence of resistance to broad-spectrum cephalosporins among Enterobacter spp. Antimicrob Agents Chemother，2001，45(9):2628-2630.
7	Rossi F，Baquero F，Hsueh PR，et al. In vitro susceptibilities of aerobic and facultatively anaerobic Gram-negative bacilli isolated from patients with intra-abdominal infections worldwide：2004 results from SMART（Study for Monitoring Antimicrobial Resistance Trends）. J Antimicrob Chemother，2006，58(1):205-210.
8	马越，李景云，张新妹，等. 1999~2002年北京、广东、湖北和辽宁地区大肠埃希氏菌及肺炎克雷伯氏菌临床分离株耐药性比较分析. 中国抗生素杂志，2004，29(4):226-234.
9	Taylor，GD，Buchanan-Chell M，Kirkland T，et al. Nosocomial Gram-Negative Bacteremia. Int J Infect Dis，1997，1(1):202-205.
10	Kim YK，Pai H，Lee HJ，et al. Bloodstream infections by extended spectrum beta-lactamase producing Escherichia coli and Klebsiella pneumoniae in children：epidemiology and clinical outcome. Antimicrob Agents Chemother，2002，46(5):1481-1491.
11	Al-Hasan MN，Razonable RR，ckel-Passow JE，et al. Incidence rate and outcome of Gram-Negative bloodstream infection in solid organ transplant recipients. Am J Transplant，2009，9(4):835-843.

敏感率（%）	厄他培南	亚胺培南	美罗培南	头孢曲松	头孢他啶	头孢西丁	头孢吡肟
大肠埃希菌（15株）	100	100	100	6.7	60	88.9	33.3
肺炎克雷伯菌（5株）	-	100	100	0	60	40	20
敏感率（%）	哌拉西林/他唑巴坦	阿米卡星	妥布霉素	环丙沙星	左旋氧氟沙星	头孢哌酮/舒巴坦	庆大霉素
大肠埃希菌（15株）	73.3	93.3	16.7	33.3	0	-	26.7
肺炎克雷伯菌（5株）	20	40	-	20	-	20	40

敏感率（%）	厄他培南	亚胺培南	美罗培南	头孢曲松	头孢他啶	头孢西丁	头孢吡肟
大肠埃希菌（15株）	100	100	100	6.7	60	88.9	33.3
肺炎克雷伯菌（5株）	-	100	100	0	60	40	20
敏感率（%）	哌拉西林/他唑巴坦	阿米卡星	妥布霉素	环丙沙星	左旋氧氟沙星	头孢哌酮/舒巴坦	庆大霉素
大肠埃希菌（15株）	73.3	93.3	16.7	33.3	0	-	26.7
肺炎克雷伯菌（5株）	20	40	-	20	-	20	40

[1]	Feihong Zhao, Yingjie Chen, Jingfang Lin, Xiaochun Zheng, Yanling Liao. Effect of ultrasound-guided peripheral nerve block on postoperative recovery following total hip or knee arthroplasty [J]. Chinese Journal of Joint Surgery(Electronic Edition), 2024, 18(04): 457-468.
[2]	Wei Xi, Wenqing Wang, Yue Liu, Yanan Wang, Xuebin Xu. Pathogenic diagnosis of ST14514 infection of gastroenteritis leading to sepsis and retrospective analysis of literatures with Vibrio vulnificus infected cases [J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2024, 18(05): 293-302.
[3]	Guanyu Zhou, Luping Tan, Yajing Yang, Xiaoguang Li. Pathogen monitoring results and clinical features of 1 916 outpatients in intestinal clinic with intestinal foodborne diseases [J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2024, 18(04): 200-206.
[4]	Kecan Lin, Liuping Luo. Key problems in the application of hepatopancreaticoduodenectomy for gallbladder cancer and cholangiocarcinoma [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(06): 774-778.
[5]	Jiaying Li, Xudan Wang, Xue Liang, lei Zhang, Jiaying Li. Analysis of mortality trends of colorectal cancer in China from 1990 to 2021 [J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2024, 13(04): 274-279.
[6]	Ming Yang, Jinzhu Zhang, Xishan Wang. Interpretation of colorectal cancer prevalence trend data from 2013 to 2022 released by the National Tumor Registry [J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2024, 13(03): 177-181.
[7]	Jinzhu Zhang, Ming Yang, Xishan Wang. Epidemiology and disease burden of colorectal cancer in China, the United States, and Worldwide: a comparative analysis and reflection [J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2024, 13(02): 89-93.
[8]	Shaoqing Zhang, Yufeng Lv, Haixia Dong. The predictive effect of neutrophil percentage-to-albumin ratio for all-cause mortality in maintenance hemodialysis patients [J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2024, 13(06): 321-326.
[9]	Xiaolong Wang, Jie Wu, Zhe Feng, Hao Wen, Shuwei Duan, Shuang Liang, Guangyan Cai. Analysis of risk factors for short-term poor prognosis in cardiology-wards patients undergoing renal replacement therapy due to acute kidney injury [J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2024, 13(05): 241-248.
[10]	Wenyu Cao, Peng Guo, Jinping Li. Reserach progress of minimally invasive surgery and non-surgical treatment for chronic subdural hematoma [J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2024, 10(05): 304-309.
[11]	Runshi Zhou, Min Zheng, Wei Han, Zunzhu Li, Chaokai He, Yi Chi, Yun Long. Effect of cluster goal-oriented nursing strategy on the 28-day prognosis of patients with septic shock caused by multi-drug resistant bacteria [J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2024, 10(03): 236-242.
[12]	Ruhai Wang, Shen Wang, Min Zhang, Chun Li, Chao Han, Qiang Yu, Haicheng Hu, Xizhen Li. Analysis of influencing factors of short-term mortality risk in patients with severe traumatic brain injury after decompressive craniectomy [J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2024, 14(05): 285-291.
[13]	Wenzhe Li, Yi Wang, Jian Cui, Qihang Zheng, Jingyan Wang, Xiangyou Yu. Critically ill patients with acute renal dysfunction in Xinjiang Uygur Autonomous Region：A crosssection study [J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2024, 10(05): 269-276.
[14]	Qingwen Liu, Yong Han, Lidan Chen, Zhe Deng. Impact of early mechanical ventilation on mortality rates in adult in-hospital cardiac arrest: a retrospective cohort study [J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2024, 10(04): 203-206.
[15]	Chinese Society for Metabolic and Bariatric Surgery (CSMBS), Chinese Society for Integrated Health of Metabolic and Bariatric Surgery (CSMBS IH), Chinese Obesity and Metabolic Surgery Collaborative (COMES Collaborative). Chinese Obesity and Metabolic Surgery Database: Annual Report 2023 [J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2024, 10(02): 73-83.

Please choose a citation manager

Content to export

A 12-year study of bloodstream infection after liver transplantation: microbial epidemiology and clinical outcome of extended-spectrum β-lactamases (ESBLs) -producing Klebsiella spp and Escherichia coli

RichHTML

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

Figures/Tables 1

References 11

Related Articles 15

Recommended Articles

Metrics

Comments

模态框（Modal）标题

Please choose a citation manager

Content to export

A 12-year study of bloodstream infection after liver transplantation: microbial epidemiology and clinical outcome of extended-spectrum β-lactamases (ESBLs) -producing Klebsiella spp and Escherichia coli

RichHTML

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

Figures/Tables 1

References 11

Related Articles 15

Recommended Articles

Metrics

Comments