Leptin and intestinal mucosal barrier

doi:10.3877/cma.j.issn.1674-0793.2014.03.013

Abstract

Abstract:

Leptin, a kind of multiple peptide hormone mainly secreted by fat cells, has a wide range of biological effects on the body, including adjusting the energy metabolism, growth and development, immune response and promoting wound repair. In recent years, with the development of the research on intestinal leptin and its receptor, leptin has been proved as a new kind of gastrointestinal hormone that has important physiological function in regulating gastrointestinal function and maintaining intestinal mucosal barrier.

Key words: Leptin, Intestinal mucosa, Proliferation, Immune, Nutrition

Song Guo, Qiangpu Chen. Leptin and intestinal mucosal barrier[J]. Chinese Archives of General Surgery(Electronic Edition), 2014, 08(03): 232-236.

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References 38

1	Cammisotto PG, Rensud C, Gingras D, et al. Endocrine and exocrine secretion of leptin by the gastric mucosa[J]. J Histecbem Cytochem, 2005, 53(7): 85l-860．
2	Attoub S, Nce V, Pirola L, et al. Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways[J]. FASEB J, 2000, 14(14): 2329-2338．
3	彭彦霄，陆震，吴学平, 等. 瘦素及其受体在人胚胎小肠不同发育阶段的表达[J].解剖学研究, 2008, 30(1): 32-34．
4	Mackey-Lawrence NM, Petri WA Jr. Leptin and mucosal immunity[J]. Mucosal Immunol, 2012, 5(5): 472-479.
5	Kiely JM, Noh JH, Graewin SJ, et al. Altered intestinal motility in leptin-deficient obese mice[J]. J Surg Res, 2005, 124(1): 98-103．
6	卢静，魏良洲，田字彬, 等. 瘦素与肠动力关系的研究进展[J]. 胃肠病学和肝病学杂志, 2008, 17(1): 83-84.
7	Iqbal J, Li X, Chang BH, et al. An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption[J]. J Lipid Res, 2010, 51(7): 1929-1942.
8	Morton NM, Emilsson V, Liu YL, et al. Leptin action in intestinal cells[J]. J Biol Chem, 1998, 273(40): 26194-26201.
9	Sukhotnik I, Coran AG, Mogilner JG, et al. Leptin affects intestinal epithelial cell turnover in correlation with leptin receptor expression along the villus-crypt axis after massive small bowel resection in a rat[J]. Pediatr Res, 2009, 66(6): 648-653.
10	Sukhotnik I, Mogilner JG, Shteinberg D, et al. Leptin accelerates enterocyte turnover during methotrexate-induced intestinal mucositis in a rat[J]. Cancer Biol Ther, 2009, 8(10): 899-906.
11	Sukhotnik I, Helou H, Lurie M, et al. The effect of leptin on intestinal recovery following ischemia-reperfusion injury in a rat[J]. Pediatr Surg Int, 2007, 23(5): 473-478.
12	Gao J, Tian J, Lv Y, et al. Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/pathways in human endometrial cancer cells[J]. Cancer Sci, 2009, 100(3): 389-395.
13	Pérez-Pérez A, Maymó J, Duenas JL, et al. Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway[J]. Arch Biochem Biophys, 2008, 477(2): 390-395.
14	Saxena NK, Sharma D, Ding X, et al. Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells[J]. Cancer Res, 2007, 67(6): 2497-2507.
15	Buttar NS, Wang KK. Mechanisms of disease: carcinogenesis in barrett's esophagus[J]. Nat Clin Pract Gastroenterol Hepatol, 2004, 1(2): 106-112.
16	陈慧，杨冬梓，蔡卫斌, 等. Leptin对缺氧诱导胎肺Ⅱ型上皮细胞凋亡的影响及机制[J].中国病理生理杂志, 2007, 23(5): 959-963．
17	Pai R, Lin C, Tran T, et al. Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation[J]. Biochem Biophys Res Commun, 2005, 331(4): 984-992.
18	Rouet-Benzineb P, Aparicio T, Guilmeau S, et al. Leptin counteracts sodium butyrate-induced apoptosis in human colon cancer HT-29 cells via NF-kappaB signaling[J]. J Biol Chem, 2004, 279(16): 16495-16502.
19	Russo VC, Metaxas S, Kobayashi K, et al. Antiapoptotic effects of leptin in human neuroblastoma cells[J]. Endocrinology, 2004, 145(9): 4103-4112.
20	Rouet-Benzineb P, Aparicio T, Guilmeau S, et al. Leptin counteracts sodium butyrate-induced apoptosis in human colon cancer HT-29 cells via NF-kappaB signaling[J]. J Biol Chem, 2004, 279(16): 16495-16502．
21	周少丽，魏涧琦，李晓芸, 等. 瘦素对缺氧复氧LO2肝细胞凋亡及Fas/FasL表达的影响[J]. 中国病理生理杂志, 2009, 25(6): 1147-1150.
22	Nishi Y, Isomoto H, Uotani S, et al. Enhanced production of leptin in gastric fundic mucosa with Helicobacter pylori infection[J]. World J Gastroenterol, 2005, 11(5): 596-699.
23	Edward O, Adeyemi, Salim A, et al. Mechanisms of action of leptin in preventing gastric ulcer[J]. World J Gastroenterel, 2005, 11(27): 4154-4160.
24	王晓辉，王录焕，薛辉, 等. 瘦素对肠缺血再灌注损伤大鼠外周血TNF-a和IL-10表达及小肠局部病理损伤的影响[J]. 第二军医大学学报, 2008, 29(3): 250-253.
25	林季，颜光涛，王录焕, 等.肠缺血再灌注损伤对leptin蛋白质及mRNA水平的影响[J]. 中国危重病急救医学, 2004, 16(11): 651-655．
26	Claycombe K, King LE, Fraker PJ. A role for leptin in sustaining lymphopoiesis and myelopoiesis [J]. Proc Natl Acad Sci USA, 2008, 105(6): 2017-2021.
27	Hsu A, Aronoff DM, Phipps J, et al. Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia[J]. Clin Exp Immunol, 2007, 150(2): 332-339．
28	Santos-Alvarez J, Goberna R, Sanchez-Margalet V. Human leptin stimulates proliferation and activation of human circulating monocytes[J]. Cell Immunol, 1999, 194(1): 6-11.
29	Zarkesh-Esfahani H, Pockley AG, Wu Z, et al. Leptin indirectly activates human neutrophils via induction of TNF-alpha[J]. J lmmunol, 2004, 172(3): 1809-1814.
30	Papathanassoglou E, EbHasehimi K, Li XC, et al. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice[J]. J Immunol, 2006, 176(12): 7745-7752．
31	Batra A, Okur B, Erben U, et al. Leptin: a critical regulator of CD4+ T-cell polarization in vitro and in vivo[J]. Endocrinology, 2010, 151(1): 56-62.
32	Lam QL, Wanq S, Ko OK, et al. Leptin signaling maintains B-cell homeostasis via induction of Bcl-2 and Cyclin D1[J]. Proc Natl Acad Sci USA, 2010, 107(31): 13812-13817.
33	王晓辉，王录焕，邓子辉, 等. 瘦素对肠缺血/再灌注损伤大鼠肝脏功能的影响及其机制[J]. 感染、炎症、修复, 2007, 8(3): 137-139.
34	颜光涛，薛辉，林季, 等. 脓毒症后瘦素对肠道功能的影响及对肝肾功能的保护作用[J]. 中国病理生理杂志, 2007, 23(8): 1566-1569.
35	李维新，严祥. 胃瘦素的研究新进展[J]. 中华老年多器官疾病杂志, 2012, 11(4): 312-315.
36	Kiely JM, Noh JH, Svatek CL, et al. Altered small intestinal absorptive enzyme activities in leptin-deficient obese mice: influence of bowel resection[J]. J Pediatr Surg, 2006, 41(7): 1243-1249．
37	Yarandi SS, Hebbar G, Sauer CG, et al. Diverse roles of leptin in the gastrointestinal tract: modulation of motility, absorption, growth, and inflammation[J]. Nutrition, 2011, 27(3): 269-275.
38	Fanjul C, Barrenetxe J, Inigo C, et al. Leptin regulates sugar and amino acids transport in the human intestinal cell line Caco-2[J]. Acta Physiol (Oxf), 2012, 205(1): 82-91.

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