Correlation between prognosis and changes in indexes of coagulation and fibrinolysis before and after operation in patients with colon carcinoma

doi:10.3877/cma.j.issn.1674-0793.2017.01.008

Abstract

Abstract:

Objective

To analyze the correlation between prognosis and changes of PT, APTT and D-dimer before and after operation in patients with colon carcinoma.

Methods

Between January 2011 and January 2015, one hundred and twenty patients with colon carcinoma were chosen as study objects, the level of PT, APTT and D-dimer in patients were detected 1 day before operation, 2 days after operation, and the variations were recorded and analyzed combined with pathological characteristics and complication rate.

Results

The variation of PT was (1.1±0.4) s, that of APTT was (5.4±2.4) s, that of D-dimer was (112.5±31.4) μg/L. After operation, hemorrhage occurred in 9 patients (7.5%), 12 patients (10.00%) developed thrombosis and embolism. The variations of PT, APTT and D-dimer demonstrated significant relativity with complications of patients (P<0.05).

Conclusions

Patients with colon carcinoma have risks of thrombosis, embolism and hemorrhage, even with no obvious abnormality on coagulation fibrinolytic markers in perioperation period. It should pay attention to clinical monitoring after opreation.

Key words: Colonic Neoplasms, Prothrombin time (PT), Partial Thromboplastin Time, D-dimer

Yanming Lin, Lijing Guo, Dapeng Fu, Shuang Yang, Lei Chen, Qiang Li, Zhiwei Wu, Qing Xu. Correlation between prognosis and changes in indexes of coagulation and fibrinolysis before and after operation in patients with colon carcinoma[J]. Chinese Archives of General Surgery(Electronic Edition), 2017, 11(01): 32-35.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2017.01.008

https://zhptwkxwx.cma-cmc.com.cn/EN/Y2017/V11/I01/32

Figures/Tables 3

References 12

[1]	唐勤彩,罗和生,全晓静, 等. 结肠癌血行转移患者的凝血功能变化[J]. 胃肠病学和肝病学杂志, 2015, 24(1): 22-24.
[2]	朱红亚,张遂,赵强, 等. 腹腔镜结肠癌手术对患者凝血状态的影响[J]. 中国现代普通外科进展, 2011, 14(4): 331-332.
[3]	张鹏军,刘英虎. 腹腔镜手术对直、结肠癌患者凝血功能与炎症因子的影响[J]. 陕西医学杂志, 2014, 43(9): 1194-1196.
[4]	林壮琼,张展青. 肝硬化患者凝血功能和血小板检测分析[J]. 检验医学与临床, 2013, 10(8): 986-987.
[5]	李卫,周铃,孙浩, 等. 止血药对结肠癌患者术后下肢深静脉血栓形成的影响[J]. 实用癌症杂志, 2013, 28(6): 709-711.
[6]	汪宏梅. 结肠癌组织中蛋白酶活化受体-1的表达及意义[J]. 国际检验医学杂志, 2013, 34(24): 3320-3321, 3323.
[7]	孙学青,韩景银. D-二聚体的临床应用[J]. 检验医学与临床, 2013, 10(2): 204-205,236.
[8]	黄文起. 围术期凝血功能调控和量化处理策略[J/CD]. 中华普通外科学文献（电子版）, 2010, 4(4): 301-303.
[9]	李卫,周铃,孙浩, 等. 止血药对结肠癌患者术后下肢深静脉血栓形成的影响[J]. 实用癌症杂志, 2013, 28(6): 709-711.
[10]	Turpin B,Miller W,Rosenfeldt L, et al. Thrombin drives tumorigenesis in colitis-associated colon cancer[J]. Cancer Res, 2014, 74(11): 3020-3030.
[11]	Adams GN,Rosenfeldt L,Frederick M, et al. Colon cancer growth and dissemination relies upon thrombin, stromal PAR-1, and fibrinogen[J]. Cancer Res, 2015, 75(19): 4235-4243.
[12]	施文武,游红勇,李兵, 等. 两种方法治疗原发性肝癌的疗效及其对C-反应蛋白和凝血功能的影响[J]. 检验医学与临床, 2013, 14(23): 3150-3152.

时间	PT（s）	APTT（s）	D-dimer（μg/L）
术前	11.3±1.4	24.8±3.8	179.8±45.6
术后	10.5±0.5	19.1±7.5	288.9±57.4
t值	5.895	7.427	16.303
P值	<0.05	<0.01	<0.01

时间	PT（s）	APTT（s）	D-dimer（μg/L）
术前	11.3±1.4	24.8±3.8	179.8±45.6
术后	10.5±0.5	19.1±7.5	288.9±57.4
t值	5.895	7.427	16.303
P值	<0.05	<0.01	<0.01

临床资料	D1		D2		D3
临床资料	r值	P值	r值	P值	r值	P值
性别	0.071	0.476	0.062	0.602	0.065	0.594
年龄	0.074	0.437	0.065	0.594	0.073	0.455
病理类型	0.132	0.211	0.126	0.215	0.121	0.255
分化程度	0.584	0.019	0.497	0.038	0.417	0.049
TNM分期	0.511	0.033	0.531	0.025	0.456	0.044
肿瘤位置	0.129	0.234	0.104	0.353	0.113	0.297
肿瘤直径	0.441	0.047	0.359	0.115	0.318	0.114

临床资料	D1		D2		D3
临床资料	r值	P值	r值	P值	r值	P值
性别	0.071	0.476	0.062	0.602	0.065	0.594
年龄	0.074	0.437	0.065	0.594	0.073	0.455
病理类型	0.132	0.211	0.126	0.215	0.121	0.255
分化程度	0.584	0.019	0.497	0.038	0.417	0.049
TNM分期	0.511	0.033	0.531	0.025	0.456	0.044
肿瘤位置	0.129	0.234	0.104	0.353	0.113	0.297
肿瘤直径	0.441	0.047	0.359	0.115	0.318	0.114

临床资料	D1		D2		D3
临床资料	r值	P值	r值	P值	r值	P值
出血	0.451	0.043	0.447	0.045	0.884	0.045
血栓及栓塞	0.827	0.000	0.941	0.000	0.475	0.000

Please choose a citation manager

Content to export