To explore the long-term clinical value of proximal gastrectomy combined with jejunal anastomosis for typeⅡ andⅢ adenocarcinoma of esophagogastric junction(AEJ) patients.

A total of one hundred and thirty-two patients with typeⅡ andⅢ AEJ were enrolled in this study from January 2014 to January 2017 in Chang’an Hospital of Xi’an City. The patients were divided into study group (62 cases) and control group (70 cases) according to the operation. The study group underwent proximal gastrectomy (PG) + interposition jejunum anastomosis, the control group underwent total gastrectomy (TG) + Roux-en-Y anastomosis. The incidence of complications such as reflux esophagitis and inverted syndrome, the nutritional status and immune function of the two groups were compared before and after operation.

The incidence of reflux esophagitis and the incidence of inverted syndrome were 22.6% and 1.6% in the study group, lower than 64.3% and 7.1% in the control group respectively (χ²=23.135, 2.317, P<0.01, 0.021). Compared with the preoperative levels, the serum total protein, albumin and hemoglobin levels of the two groups were significantly lower 6 months after operation. The ratio of LgA, LgG and CD4+/CD8+ increased significantly (all P<0.05). Between the two groups, nutritional status, body weight loss in study group were significantly lower than the control group, the differences were statistically significant (both P<0.05), but there was no significant difference in immune function indexes.

The combination of proximal gastrectomy for typeⅡandⅢ AEJ patients can improve the long-term quality of life and improve the nutritional status and immune function of the patients, with less complications of long-term clinical value.