With the aging of the population, the incidence of lower extremity arterial stenosis and occlusive disease is getting higher and higher, and the endovascular stents have been widely used, thus the incidence of in-stent restenosis is also increasing. At present, the techniques used for the treatment of ISR include drug therapy, plain balloon, drug-coated balloon, bare-metal stent, drug-eluting stent, intracavity volume reduction (laser atherectomy, excisional atherectomy) and bypass surgery. The effects of single treatment methods are limited, and intracavitary volume reduction combined with drug-coated balloon can mechanically remove the proliferating intima and effectively inhibit the intimal hyperplasia, which is a reasonable method for the treatment of in-stent restenosis.