To compare and analyze the clinical effects of D3 lymphadenectomy in right colon cancer with different medial boundaries.

From January 2018 to December 2020, 56 patients with right colon cancer undergoing laparoscopic D3 lymphadenectomy in the People’s Hospital of Chizhou were selected as the research objects. The patients were randomly divided into two groups, with 28 patients in each group. The left side of the superior mesenteric artery (SMA group) or the left side of the superior mesenteric vein (SMV group) were used as the medial boundary for laparoscopic D3 lymphadenectomy of right colon cancer. The perioperative related indexes, postoperative complications and postoperative survival were compared between the two groups.

The total number of lymphadenectomy and positive lymph nodes in SMA group were significantly higher than those in SMV group (P<0.05). There were no significant differences between the two groups in terms of operation time, intraoperative bleeding volume, postoperative drainage volume, exhaust time, hospital stay, and total incidence of postoperative complications. The cumulative disease-free survival rate (82.1% vs 71.4%) and cumulative overall survival rate (89.3% vs 78.6%) in SMA group were slightly higher than those in SMV group, but the differences were not statistically significant (χ²=0.995, 1.402; P=0.319, 0.236).

Laparoscopic D3 lymphadenectomy for right colon cancer with the left side of SMV or the left side of SMA as the medial boundary is safe and feasible. On the basis of ensuring the radical treatment of the tumor, the left side of SMA as the medial boundary can be used to remove the lymph node more thoroughly, improve the degree of radical treatment of the tumor without significantly increasing the risk of surgery, and is conducive to improving the prognosis of patients.