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Chinese Archives of General Surgery(Electronic Edition) ›› 2024, Vol. 18 ›› Issue (03): 229-234. doi: 10.3877/cma.j.issn.1674-0793.2024.03.011

• Review • Previous Articles    

Advances and correlation in molecular classification of gastric cancer

Huanhuan Wang1, Shaoxiang Zheng1, Jinjin Hao1, Wenliang Chen2,()   

  1. 1. Graduate Department of Shanxi Medical University, Taiyuan 030001, China
    2. Department of General Surgery, the Second Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2023-12-18 Online:2024-06-01 Published:2024-06-13
  • Contact: Wenliang Chen

Abstract:

Gastric cancer is a common malignant tumor of digestive tract, and its high heterogeneity is one of the thorny problems in the diagnosis and treatment of gastric cancer. At present, the traditional treatment strategies for gastric cancer classification are not perfect, so the research on molecular classification of gastric cancer is extremely necessary. In this paper, two landmark molecular classifications of The Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG) were reviewed, and different molecular classifications of recent gastric cancer were further elaborated from the aspects of single-cell RNA sequencing, lncRNA, epigenetics, and immune infiltration. The different molecular characteristics and biological behaviors of each type as well as the relationship between different subtypes were described. The gene targets and mechanism pathways of their action may be explored, which helps improve the outcomes and provides basis for targeted therapy for specific subtypes.

Key words: Molecular classification, Stomach neoplasms, scRNA-seq, lncRNA, Immune infiltration, Epigenomics, In situ hybridization

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