Abstract:

Objective

To investigate the correlation clinical factors of the calculus of intrahepatic duct with cholangiocarcinoma.

Methods

Investigation was taken in 420 operated cases with intrahepatic bile duct stone， including age， combined liver diseases and the course of biliary infection. In 80 cases suspected cholangiocarcinoma， the biliary inflammation mucous membranes tissue of the stone position were obtained through a choledochoscope， the DNA content and the Agnor particle counting were analyzed in the above tissue.

Results

7 of 47 patients combined cholangiocarcinoma whose age above 50， combined liver cirrhosis with C or B hepatitis and the history of infection of biliary tract was more than 10 years (14.8%).The means of DNA content and the Agnor particle counting gradually stepped up in the simple hyperplasy，low，middleandhighdegreeatypismhyperplasyandthewell，moderately，poorlydifferentiatedcholangiocarcinoma tissue. There was no significantly difference between the simple hyperplasy and the low degree atypism hyperplasy group (P>0.05). And the DNA content and the Agnor particle counting differences between the other two groups were significant (P<0.05).

Conclusion

The development in the cholangiocarcinoma patients with intrahepatic bile duct stone may be thus process: repeatedly inflammation stimulated， bile duct epithelial proliferation and metaplasia and then cancerogenesis.

Key words: Intrahepatic bile duct, Calculus, Cholangiocarcinoma