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Chinese Archives of General Surgery(Electronic Edition) ›› 2009, Vol. 03 ›› Issue (05): 58-60. doi: 10.3877/cma.j.issn.1674-0793.2009.05.021

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Chao-xu ZHENG1,(), Kai-tao YUAN1, Liu-hua CHEN1, Min TAN1   

  1. 1.Department of Minimal Invasive Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
  • Received:2009-04-09 Online:2009-10-01 Published:2024-12-01
  • Contact: Chao-xu ZHENG

Abstract:

Objective

To evaluate the safety of laparoscopic Nissen fundoplication (LNF)for gastroesophageal reflux disease(GERD).

Methods

The electronic databases(MEDLINE,EMBASE,PubMed,Cochrane Library, CBM, CNKI) were searched, and relevant chinese articles were also sought manually. The randomised controlled trails (RCTs)on LNF vs open nissen fundoplication (ONF)were identified.RevMan 4.2.2 software was used for statistical analysis.

Results

Six RCTs(which comprised 442 patients)on LNF vs ONF were included.No death was observed after the procedures in both groups.The result of Meta-analysis showed that there was statistical significant difference in incidence of complications between LNF and ONF (P<0.05).

Conclusion

LNF is more safe than the open procedure for GERD.RCTs with large series and high quality are required to confirm this argument.

Key words: Fundoplication; Laparoscopic surgery procedures; Gastroesophageal reflux; Complications;Meta-analysis

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