Abstract:

Objective

To investigate the clinical pathological and biology features of breast carcinosarcoma, find some important information for integrate surgical treatment.

Methods

The histopathology and immunophenotype of 26 cases breast carcinosarcoma and 30 cases breast cacinoma were reviewed.Clinical data such as operation,pathological and biology features were studied.

Results

In all cases,61.54%of all cases were composed of more than half of carcinoma, with 30.77% of that had axillary lymph nodes metastatic tumor. 38.46%were composed of more than half of sarcoma,30.77%had axillary lymph nodes metastatic tumor with no axillary lymphnodesmetastatictumor.ImmunohistochemistryresultsshowedpositiverateofEMA,CK,P53,ER,PR in carcinoma issues were 96.15%,96.15%,53.85%,61.54%and 30.77%.And that of Vimentin and S100 were 19.23%and 15.38%,respectively.The positive rate of EMA,CK,P53,ER,PR in sarcoma issues were 19.23%,11.54%,7.69%,3.85%,3.85%.And that of Vimentin and S100 were 96.15%and 88.46%,respectively.There was no statistical difference between two groups in the terms of EMA and CK.

Conclusions

Primary carcinosarcoma of the breastis fountainhead blend of malignant epithelium and phyllodes tumor,which is a sort of invasive malignant tumor with high recurrence.Integrate treatmentmay be effective.

Key words: Breastneoplasms, Carcinosarcoma, Pathology, Biologicalmarker