Clinical study on application of early enteral nutrition combined with Somatostatin in the after colorectal cancer surgery

doi:10.3877/cma.j.issn.1674-0793.2009.06.014

Abstract

Abstract:

Objective

To investigate the therapeutic effect,safety and the resumption of gastrointestinal function of early enteral nutrition (EEN)combined with Somatostatin (SS)in the patients after colorectal cancer surgery.

Methods

80 patients who accepted colorectal cancer surgery were selected and randomly divided into two groups,including 40 cases of treatment group with SS on the basis of EEN and 40 cases of control group with EEN,Some aspects were analyzed between the two groups before and after the operations,which includes the times of recovering peristalsis and passing flatus,promoted clinical manifestation and signs,gastrointestinal decompression,blood routine examinations, liver and renal function,blood glucose,electrolytes and so on.

Results

As for clinical manifestation and sign promotion,there was statistically significance in the alleviation of pain and distension of the abdominal (P<0.05)and the average volume of gastrointestinal decompression (P<0.01)between the treatment group and the control group after 2 d of surgery. It indicated the treatment group was better than the control group in therapeutic results.As for times of recovering peristalsis and passing flatus,blood routine examinations, liver and renal function, blood glucose, electrolytes, there were no statistically significance between the treatment group and the control group.It indicated the therapeutic effect of SS dose not depress the effect of EEN.

Conclusions

EEN combined with SS is a safe and effective peri-operation treatment, can obviously promote clinical symptom,and increase the achievement ratio of expectant treatment.

Key words: Colorectalcancer, Surgicalprocedures, Enteralnutrition, Somatostatin

Shi-qi HU, Zhen-bang LIU, Xi-wen CHEN, Ping YANG, Wei-biao TANG. Clinical study on application of early enteral nutrition combined with Somatostatin in the after colorectal cancer surgery[J]. Chinese Archives of General Surgery(Electronic Edition), 2009, 03(06): 503-506.

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Figures/Tables 3

References 12

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组别	Hb（g/L）	Tp（g/L）	Alb（g/L）	Pa（mg/L）	Glu（mmol/L）	K^＋（mmol/L）	Na^＋（mmol/L）	Cl^-（mmol/L）	Ca²⁺（mmol/L）
术前试验组	115.12±23.78	61.56±10.89	34.65±8.67	0.85±4.92	5.87±1.65	3.69±0.45	149.65±5.34	103.14±4.99	2.25±13.98
对照组	113.34±21.56	62.78±11.56	35.37±5.34	0.74±3.29	6.23±2.452	3.78±0.61	136.24±4.18	105.75±4.55	2.19±12.56
术后3d试验组	112.85±22.78	58.78±7.89	31.22±5.91	0.14±0.06	6.95±2.35	3.98±0.32	139.32±4.58	106.82±3.99	2.42±0.35
对照组	110.42±16.15	60.67±6.55	33.56±5.34	0.16±0.13	6.46±1.54	4.15±0.56	142.77±4.78	105.76±4.78	2.35±0.78
术后7d试验组	108.13±25.35	61.85±7.98	31.52±4.33	0.15±0.08	6.33±2.35	4.02±0.38	138.13±5.21	103.58±3.85	2.25±0.38
对照组	112.66±21.88	62.53±7.32	30.75±4.21	0.13±0.15	6.52±2.89	3.59±0.69	136.93±5.39	102.88±3.93	2.38±0.25

组别	Hb（g/L）	Tp（g/L）	Alb（g/L）	Pa（mg/L）	Glu（mmol/L）	K^＋（mmol/L）	Na^＋（mmol/L）	Cl^-（mmol/L）	Ca²⁺（mmol/L）
术前试验组	115.12±23.78	61.56±10.89	34.65±8.67	0.85±4.92	5.87±1.65	3.69±0.45	149.65±5.34	103.14±4.99	2.25±13.98
对照组	113.34±21.56	62.78±11.56	35.37±5.34	0.74±3.29	6.23±2.452	3.78±0.61	136.24±4.18	105.75±4.55	2.19±12.56
术后3d试验组	112.85±22.78	58.78±7.89	31.22±5.91	0.14±0.06	6.95±2.35	3.98±0.32	139.32±4.58	106.82±3.99	2.42±0.35
对照组	110.42±16.15	60.67±6.55	33.56±5.34	0.16±0.13	6.46±1.54	4.15±0.56	142.77±4.78	105.76±4.78	2.35±0.78
术后7d试验组	108.13±25.35	61.85±7.98	31.52±4.33	0.15±0.08	6.33±2.35	4.02±0.38	138.13±5.21	103.58±3.85	2.25±0.38
对照组	112.66±21.88	62.53±7.32	30.75±4.21	0.13±0.15	6.52±2.89	3.59±0.69	136.93±5.39	102.88±3.93	2.38±0.25

组别		AST（IU/L）	ALT（IU/L）	ALP（IU/L）	r-GT（IU/L）	Tb（mmol/L）	Db（mmol/L）	BUN（mmol/L）	Scr（mol/L）
手术前	试验组	31.54±38.67	28.98±35.23	75.89±43.22	45.12±35.67	18.54±21.69	12.55±9.88	4.38±2.16	82.45±26.82
	对照组	31.23±34.78	28.65±45.78	86.55±19.98	49.08±33.85	12.83±28.91	9.85±6.33	4.92±3.88	81.05±23.77
手术后3d	试验组	27.93±18.55	28.23±15.33	64.82±23.34	37.65±45.21	15.86±35.19	7.62±8.49	4.51±2.83	74.84±23.29
	对照组	30.85±34.62	29.15±18.85	75.88±28.96	42.18±25.85	16.14±30.53	8.11±6.83	4.45±2.09	76.06±18.59
手术后7d	试验组	21.99±9.35	28.02±15.62	79.45±27.25	48.15±36.77	16.99±33.15	8.59±12.33	4.09±2.49	76.95±23.65
	对照组	23.45±8.78	27.89±20.62	79.58±32.91	47.83±32.53	15.69±31.56	7.83±16.73	4.85±2.02	78.61±25.38

组别		AST（IU/L）	ALT（IU/L）	ALP（IU/L）	r-GT（IU/L）	Tb（mmol/L）	Db（mmol/L）	BUN（mmol/L）	Scr（mol/L）
手术前	试验组	31.54±38.67	28.98±35.23	75.89±43.22	45.12±35.67	18.54±21.69	12.55±9.88	4.38±2.16	82.45±26.82
	对照组	31.23±34.78	28.65±45.78	86.55±19.98	49.08±33.85	12.83±28.91	9.85±6.33	4.92±3.88	81.05±23.77
手术后3d	试验组	27.93±18.55	28.23±15.33	64.82±23.34	37.65±45.21	15.86±35.19	7.62±8.49	4.51±2.83	74.84±23.29
	对照组	30.85±34.62	29.15±18.85	75.88±28.96	42.18±25.85	16.14±30.53	8.11±6.83	4.45±2.09	76.06±18.59
手术后7d	试验组	21.99±9.35	28.02±15.62	79.45±27.25	48.15±36.77	16.99±33.15	8.59±12.33	4.09±2.49	76.95±23.65
	对照组	23.45±8.78	27.89±20.62	79.58±32.91	47.83±32.53	15.69±31.56	7.83±16.73	4.85±2.02	78.61±25.38

组别	例数	肠蠕动恢复时间(h)	肛门排气时间(h)	腹痛、腹胀发生率(％)	胃肠减压量(ml/d)
试验组	40	35.37±5.43	63.17±7.65	35.0(14/40)	189±94.95
对照组	40	33.89±4.58	61.58±7.15	65.0(26/40)	389±124.3
F值		0.41	0.02	10.24	2.29
P值		0.14	0.29	0.044	0.000

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