Abstract:
Objective To investigate whether serum vascular endothelial growth factor-C(sVEGF-C) and multidetector CT(MDCT) have relationships with lymph node metastasis(LNM) in colorectal cancer.
Methods The sVEGF-C level of 110 patients and 40 donors were examined by ELISA.Both plain and enhanced MDCT scan of abdomen were performed.Detailed pathologic findings were recorded.
Results The level of sVEGF-C was higher in colorectal cancer group than in control group [(889.2±264.0)μg/L vs (373.2±97.3)μg/L]. As a cutoff value being 996.2μg/L, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of sVEGF-C for predicating LNM were 57.1%, 85.0%, 67.3%, 87.0%, 53.0%, respectively. MDCT were used to detect the LNM, the sensitivity, specificity, accuracy, positive, negative predictive value were 51.4%, 70.0%, 58.2%, 75.0%, 45.2%, respectively. When sVEGF-C associated with spiral CT were employed to diagnosis the LNM in colorectal cancer, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value was 75.7%, 92.5%, 81.8%, 94.6%, 68.5%, respectively.
Conclusion sVEGF-C associated with MDCT can be used as a preoperative methode for diagnosis of LNM in colorectal cancer.
Key words:
Colorectal neoplasms,
Vascular endothelial growth factor C,
Lymphatic metastasis,
Heliacal CT
Tian-bao WANG, Jin WANG, Lu-ying TANG, Bo WEI, Wen-guang DONG. Analysis of methods for diagnosis of lymph node metastasis of colorectal cancer[J]. Chinese Archives of General Surgery(Electronic Edition), 2010, 04(03): 208-211.