Progress in research of gene treatment for liver cirrhosis with bone marrow mesenchymal stem cells

doi:10.3877/cma.j.issn.1674-0793.2011.03.021

Abstract

Abstract:

The key of treatment for liver cirrhosis with bone marrow mesenchymal stem cells lies in the promotion of hepatocellular regeneration and the inhibition of liver tissue fibrosis. However, it’s not effective to treat liver cirrhosis with bone marrow mesenchymal stem cells alone. For We know that bone marrow mesenchymal stem cells would be fine gene carriers, it can improve the result to treat liver cirrhosis with bone marrow mesenchymal stem cells carrying target gene, which be proved by related research via many experiment methods in-vitro and in-vivo. It brings a new treatment strategy for liver cirrhosis.

Key words: Gene, Bone marrow mesenchymal stem cells, Liver cirrhosis, Cytokine

Ming-liang LI, Mei-hai DENG. Progress in research of gene treatment for liver cirrhosis with bone marrow mesenchymal stem cells[J]. Chinese Archives of General Surgery(Electronic Edition), 2011, 05(03): 252-255.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2011.03.021

https://zhptwkxwx.cma-cmc.com.cn/EN/Y2011/V05/I03/252

References 37

1	Mosca JD, Hendricks JK, Buyaner D, et al. Mesenchymal stem cells as vehicles for gene delivery. Clin Orthop Relat Res, 2000, 379 (Suppl): 71-90.
2	Lee K, Majumdar MK, Buyaner D, et al. Human mesenchymal stem cells maintain transgene expression during expansion and differentiation. Mol Ther, 2001, 3(6): 857-866.
3	Petersen BE, Bowen WC, Patrene KD, et al. Bone marrow as a potential source of hepatic oval cells. Science, 1999, 284(5417): 1168-1170.
4	Theise ND, Badve S, Saxena R, et al. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology, 2000, 31(1): 235-240.
5	Theise ND, Nimmakayalu M, Gardner R, et al. Liver from bone marrow in humans. Hepatology, 2000, 32(1): 11-16.
6	Crosby HA, Kelly DA, Strain AJ. Human hepatic stem-like cells isolated using c-kit or CD34 can differentiate into biliary epithelium. Gastroenterology, 2001, 120(2): 534-544.
7	Okumoto K, Saito T, Hattori E, et al. Differentiation of rat bone marrow cells cultured on artificial basement membrane containing extracellular matrix into a liver cell lineage. J Hepatol, 2005, 43(1): 110-116.
8	Wang YF, Nan X, Yu CZ, et al. Differentiation of bone marrow derived Thy-1+ beta2M- cells into liver cells in AA induced liver injury micro-environment. Zhonghua Gan Zang Bing Za Zhi, 2005, 13(4): 274-277.
9	Iimuro Y, Brenner DA. Matrix metalloproteinase gene delivery for liver fibrosis. Pharm Res, 2008, 25(2): 249-258.
10	Ball SG, Shuttleworth AC, Kielty CM. Direct cell contact influences bone marrow mesenchymal stem cell fate. Int J Biochem Cell Biol, 2004, 36(4): 714-727.
11	Ponte AL, Marais E, Gallay N, et al. The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells, 2007, 25(7): 1737-1745.
12	Gao J, Dennis JE, Muzic RF, et al. The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion. Cells Tissues Organs, 2001, 169(1): 12-20.
13	Fang B, Shi M, Liao L, et al. Systemic infusion of FLK1(+) mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice. Transplantation, 2004, 78(1): 83-88.
14	Forbes SJ, Russo FP, Rey V, et al. A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis. Gastroenterology, 2004, 126(4): 955-963.
15	Baba S, Fujii H, Hirose T, et al. Commitment of bone marrow cells to hepatic stellate cells in mouse. J Hepatol, 2004, 40(2): 255-260.
16	Studeny M, Marini FC, Champlin RE, et al. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res, 2002, 62(13): 3603-3608.
17	Lee KD, Kuo TK, Whang-Peng J, et al. In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology, 2004, 40(6): 1275-1284.
18	Oyagi S, Hirose M, Kojima M, et al. Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats. J Hepatol, 2006, 44(4): 742-748.
19	Lee TH, Jawan B, Chou WY, et al. Alpha-melanocyte-stimulating hormone gene therapy reverses carbon tetrachloride induced liver fibrosis in mice. J Gene Med, 2006, 8(6): 764-772.
20	Iimuro Y, Fujimoto J. Strategy of gene therapy for liver cirrohosis and hepatocellular carcinoma. J Hepatobiliary Pancreat Surg, 2003, 10(1): 45-47.
21	Schwartz RE, Reyes M, Koodie L, et al. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest, 2002, 109(10): 1291-1302.
22	Yamamoto N, Terai S, Ohata S, et al. A subpopulation of bone marrow cells depleted by a novel antibody, anti-Liv8, is useful for cell therapy to repair damaged liver. Biochem Biophys Res Commun, 2004, 313(4): 1110-1118.
23	Oe H, Kaido T, Mori A, et al. Hepatocyte growth factor as well as vascular endothelial growth factor gene induction effectively promotes liver regeneration after hepatectomy in Solt-Farber rats. Hepatogas troenterology, 2005, 52(65): 1393-1397.
24	Hung SC, Lu CY, Shyue SK, et al. Lineage differentiation-associated loss of adenoviral susceptibility and Coxsackie-adenovirus receptor expression in human mesenchymal stem cells. Stem Cells, 2004, 22(7): 1321-1329.
25	Wang LS, Duan HF, Hu JW, et al. Treatment of CCl4 induced chronic liver injury with bone marrow mesenchymal stem cells overexpressing hepatocyte growth factor. Zhonghua Gan Zang Bing Za Zhi, 2005, 13(12): 934-936.
26	Skarpen E, Oksvold MP, Grosvik H, et al. Altered regulation of EGF receptor signaling following a partial hepatectomy. J Cell Physiol, 2005, 202(3): 707-716.
27	徐迎新, 王文杰, 宋旭华, 等. 骨髓间充质干细胞定向肝细胞样分化的研究. 中华实验外科杂志, 2004, 21(2):152-153.
28	何忠杰, 方驰华, 马俊勋, 等. 肝细胞生长因子与表皮细胞生长因子联合诱导大鼠骨髓间充质干细胞分化为类肝细胞. 解放军医学杂志, 2006, 31(5):446-449.
29	Lin N, Lin J, Bo L, et al. Differentiation of bone marrow-derived mesenchymal stem cells into hepatocyte-like cells in an alginate scaffold. Cell Prolif, 2010, 43(5): 427-434.
30	吴玉卓, 张玉婷, 毛小荣, 等. EGF和HGF体外诱导肝硬化患者骨髓间充质干细胞向肝细胞分化的实验研究. 第三军医大学学报, 2008, 30(16):1541-1544.
31	Russo FP, Alison MR, Bigger BW, et al. The bone marrow functionally contributes to liver fibrosis. Gastroenterology, 2006, 130(6): 1807-1821.
32	Wang J, Bian C, Liao L, et al. Inhibition of hepatic stellate cells proliferation by mesenchymal stem cells and the possible mechanisms. Hepatol Res, 2009, 39(12): 1219-1228.
33	Kim WH, Matsumoto K, Bessho K, et al. Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis. Am J Pathol, 2005, 166(4): 1017-1028.
34	Parekkadan B, van Poll D, Megeed Z, et al. Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells. Biochem Biophys Res Commun, 2007, 363(2): 247-252.
35	Kinnaird T, Stabile E, Burnett MS, et al. Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation, 2004, 109(12): 1543-1549.
36	Flanders KC. Smad3 as a mediator of the fibrotic response. Int J Exp Pathol, 2004, 85(2): 47-64.
37	Hung KS, Lee TH, Chou WY, et al. Interleukin-10 gene therapy reverses thioacetamide-induced liver fibrosis in mice. Biochem Biophys Res Commun, 2005, 336(1): 324-331.

[1]	Jian Zhang, Xiaolong Liu, Tianjian Zha, Junjie Yao, Jie Wang. Effect of platelet-rich plasma combined with xenogeneic acellular dermal matrix in the repair of ischemic wound of diabetic foot [J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2023, 18(06): 503-506.
[2]	Dechen Wang, Kang Yang, Zijie Yang, Mingbin Gui, Lianping Qu, Xiaofeng Zhang, Feng Gao. Progress of microsatellite stability state and PD-1/PD-L1/IDO in colorectal carcinoma [J]. Chinese Archives of General Surgery(Electronic Edition), 2023, 17(06): 462-465.
[3]	Xiaolin Ye, Yunfei Liu, Mingquan Pang, Haijiu Wang, Li Ren, Lizhao Hou, Wenhao Yu, Zhixin Wang, Haining Fan. Research progress on the sources and regulatory mechanisms of liver regenerative cells [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 96-99.
[4]	Jianmei Li, Jingjuan Deng, Qian Yang. Safety and follow-up evaluation of the combined treatment of hepatocellular carcinoma with hepatic cirrhosis and portal hypertension [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 41-44.
[5]	Fangyuan Wu, Xia Sun, Changfeng Lin, Zhensheng Zhang. Risk factors of HBV-associated cirrhosis complicated with acute upper gastrointestinal bleeding [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 45-47.
[6]	Zibo Zhen, Jinhu Liu. To explore the influencing factors of postoperative intestinal dysfunction in patients undergoing laparoscopic cholecystectomy under intravenous general anesthesia based on the nomogram model [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 61-65.
[7]	Lichao Fan, Jinying Guo, Xin Chen. The significance of detection of wild-type RET and RET/PTC fusion gene for lymph node dissection in the central region of papillary thyroid carcinoma [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(06): 631-635.
[8]	Xian Mo, Chuang Yang. Meta-analysis of risk factors for portal vein thrombosis in patients with cirrhosis [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(06): 678-683.
[9]	Yutao Yuan, Jinlin Xing, Kefei Xie, Kai Yin. Correlation between CT findings and BRAF^V600E gene mutation and central lymph node metastasis in papillary thyroid carcinoma [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(06): 611-614.
[10]	Jing Tian, Xiuchun Fang. The application effect of ultrasound-guided transverse fascial plane block in pediatric inguinal hernia surgery [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2023, 17(06): 740-744.
[11]	Dingwei Xu, Jiangyun Ma, Xincheng Li, Jie Huang. Alagille syndrome misdiagnosed as congenital biliary atresia: a case report and literature review [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 681-687.
[12]	An Chen, Juan Feng, Zhenyu Yang, Xilin Du, Qiangshan Bai, Jikai Yin, Li Zang, Jianguo Lu. Analysis of CCN4 expression and its clinical significance in hepatocellular carcinoma based on bioinformatics [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 702-707.
[13]	Meina Li, Yanli Song, Shanshan Yang, Jucai Li, Huili Luo, Jie Lyu. Application and effectiveness evaluation of the triple pre-rehabilitation strategy in the perioperative period of patients with degenerative scoliosis [J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2023, 09(06): 356-364.
[14]	Zhenshuang Du, Qingfu Hu, Yingyi Lin, Yuexia Zhang, Meili Chen, Yiqi Li, Zhenhua Wang. Factors influencing motivation of community general practitioners [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(08): 876-883.
[15]	Feifei Wang, Guanglin Wang, Zesong Meng, Baokun Li, Longfei Cao, Juan Zhang, Chaoxi Zhou, Yuanyi Ding, Guiying Wang. Effect of IMPDH1 knockdown on biological behavior of human colon cancer SW480 and HT29 cells [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(08): 884-890.

Please choose a citation manager

Content to export