Interaction between Helicobacter pyloriand CD14-159C/T polymorphism in gastric cancer in Jingmen district

doi:10.3877/cma.j.issn.1674-0793.2015.06.006

Abstract

Abstract:

Objective

To study the relationship between CD14-159C/T polymorphism and susceptibility to gastric cancer and their interaction with Helicobacter pylori in Jingmen district.

Methods

Genotypes of 127 patients with gastric cancer and 127 healthy subjects were examined by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). The unconditional Logistic regression (ULR) was performed to assess the gastric cancer risk and interaction with Helicobacter pylori.

Results

There was increased risk of developing gastric cancer for CC/CT genotype carriers compared with TT genotype carriers (OR=1.35, 95% CI=1.22-2.56, P=0.000; Adjusted OR=1.61, 95% CI=1.21-3.01, P=0.000). By using the ULR method, Helicobacter pylori-positive subjects with genotype CT/CC were at a risk of 3.39 times higher than that of Helicobacter pylori-negative subjects with genotype TT (OR=3.39, 95% CI=2.66-5.36, P=0.000) (RERI=1.94, 95% CI=1.41-2.77; API=0.59, 95% CI=0.33-0.84; S=1.46, 95% CI=1.37-2.66).

Conclusion

CD14-159C/T polymorphism is associated with increased risk for gastric cancer, and its interaction with Helicobacter pylori has synergistic effects on risk of gastric cancer in Jingmen district.

Key words: Stomach neoplasms, Helicobacter pylori, CD14, Polymorphism, Susceptibility, Interaction

Xin Li, Mi Tian, Cheng Wang, Mei Wang, Huiming Ren. Interaction between Helicobacter pyloriand CD14-159C/T polymorphism in gastric cancer in Jingmen district[J]. Chinese Archives of General Surgery(Electronic Edition), 2015, 09(06): 437-440.

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URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2015.06.006

https://zhptwkxwx.cma-cmc.com.cn/EN/Y2015/V09/I06/437

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References 12

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基因型	基因分布		校正前		校正后
基因型	对照组	病例组	OR（95% CI）	P值	OR^a（95% CI）	P值
TT	74	87	1	?	?	?
CT	43	29	1.14（1.05,1.52）	0.038	1.17（1.09,1.71）	0.007
CC	10	11	1.54（1.22,2.89）	0.000	1.61（1.30,3.01）	0.000
CT/CC	52	40	1.35（1.22,2.56）	0.000	1.61（1.21,3.01）	0.000

基因型	基因分布		校正前		校正后
基因型	对照组	病例组	OR（95% CI）	P值	OR^a（95% CI）	P值
TT	74	87	1	?	?	?
CT	43	29	1.14（1.05,1.52）	0.038	1.17（1.09,1.71）	0.007
CC	10	11	1.54（1.22,2.89）	0.000	1.61（1.30,3.01）	0.000
CT/CC	52	40	1.35（1.22,2.56）	0.000	1.61（1.21,3.01）	0.000

基因型	感染	分组		OR a add（95% CI）	P a add	OR a multi（95% CI）
基因型	感染	病例组	对照组	OR a add（95% CI）	P a add	OR a multi（95% CI）
TT	否	42	54	1	?	1.47（1.09,2.17）
CT/CC	否	32	33	1.26（1.12,1.97）	0.024	?
TT	是	40	21	1.19（1.06,2.14）	0.041	?
CT/CC	是	13	19	3.39（2.66,5.36）	0.000	?
RERI	?	?	?	1.94（1.41,2.77）	?	?
API	?	?	?	0.59（0.33,0.84）	?	?
S	?	?	?	1.46（1.37,2.66）	?	?

基因型	感染	分组		OR a add（95% CI）	P a add	OR a multi（95% CI）
基因型	感染	病例组	对照组	OR a add（95% CI）	P a add	OR a multi（95% CI）
TT	否	42	54	1	?	1.47（1.09,2.17）
CT/CC	否	32	33	1.26（1.12,1.97）	0.024	?
TT	是	40	21	1.19（1.06,2.14）	0.041	?
CT/CC	是	13	19	3.39（2.66,5.36）	0.000	?
RERI	?	?	?	1.94（1.41,2.77）	?	?
API	?	?	?	0.59（0.33,0.84）	?	?
S	?	?	?	1.46（1.37,2.66）	?	?

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