Comparison of the characteristics of central papillomas and peripheral papillomas

doi:10.3877/cma.j.issn.1674-0793.2017.03.006

Abstract

Abstract:

Objective

To investigate and compare the characteristics and prognosis of intraductal papilloma (IP) and intraductal papillomatosis (IPS).

Methods

The clinical data of one hundred and nineteen cases diagnosed as IP and IPS by pathology were collected and analyzed retrospectively, with 76 IP patients and 43 IPS patients. They were followed up for 1 to 7 years.

Results

All patients were female, aged from 12 to 79 years old, with a median age of 45 years old. Both of the two diseases mainly distributed from 30 to 49 years old. Compared with IP, IPS patients were more likely to have atypical hyperplasia (11.8% vs 41.9%) , with significant difference (χ²=14.108, P=0.000), and malignant component (χ²=8.602, P =0.003). Ultrasonography was more sensitive than mammography when the two types of diseases showed as mass (χ²=66.234, P<0.01). The accuracy rate of fiberoptic ductoscopy in the patients with nipple discharge was very high (84.1%), especially in IPS patients (χ²=7.729, P=0.005). Both of the two types diseases may recur, with higher percentage in IPS (χ²=6.426, P=0.011).

Conclusions

Atypical hyperplasia and malignant tumour are more likely observed in IPS patients. Ultrasound is more sensitive than mammography when the two diseases showed as mass. Peripheral papillomas is more inclined to recur and needs more attention.

Key words: Papillomas, Hyperplasia, Recurrence, Ultrasonography

Jin Gao, Wei Tang, Xigang Ye, Lun Chen, Weige Tan, Lingxiao Pan, Xiaoshen Zhang, Wenbo Zheng. Comparison of the characteristics of central papillomas and peripheral papillomas[J]. Chinese Archives of General Surgery(Electronic Edition), 2017, 11(03): 168-171.

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References 13

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组别	例数	乳头溢液	肿物	超声发现	钼靶发现	伴AH	癌变
IP	76	49（64.5）	42（55.3）	41（53.9）	7（9.2）	9（11.8）	5（6.6）
IPS	43	21（48.8）	29（67.4）	31（72.1）	5（11.6）	18（41.9）	14（32.6）
χ²值		2.770	1.693	3.784	0.177	14.108	8.602
P值		0.096	0.193	0.052	0.674	0.000	0.003

组别	例数	乳头溢液	肿物	超声发现	钼靶发现	伴AH	癌变
IP	76	49（64.5）	42（55.3）	41（53.9）	7（9.2）	9（11.8）	5（6.6）
IPS	43	21（48.8）	29（67.4）	31（72.1）	5（11.6）	18（41.9）	14（32.6）
χ²值		2.770	1.693	3.784	0.177	14.108	8.602
P值		0.096	0.193	0.052	0.674	0.000	0.003

组别	例数	主动	被动	溢血	无色浆液	单孔	多孔
IP	49	6（12.2）	43（87.8）	33（67.3）	12（24.5）	47（95.9）	2（4.1）
IPS	21	4（19.0）	17（81.0）	12（57.1）	7（33.3）	18（85.7）	3（14.3）

组别	例数	主动	被动	溢血	无色浆液	单孔	多孔
IP	49	6（12.2）	43（87.8）	33（67.3）	12（24.5）	47（95.9）	2（4.1）
IPS	21	4（19.0）	17（81.0）	12（57.1）	7（33.3）	18（85.7）	3（14.3）

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