Research progress on the antitumour mechanism of α-Mangostin

doi:10.3877/cma.j.issn.1674-0793.2019.02.016

Abstract

Abstract:

α-Mangostin is the most bioactive anoxanthone compound isolated from the shell of mangosteen. Many studies have found that α-Mangostin has antitumor effect, such as that it can induce cell cycle arrest, inhibit cell survival, induce apoptosis and differentiation, reduce inflammation and adhesion, and reduce the invasion and metastasis of cancer cells. This article reviews the recent studies on the antitumor effect of α-Mangostin to provide valuable directions for the development and application of anti-tumor drug.

Key words: Antineoplastic agents, Phytogenic, α-Mangostin, Garcinia mangostana, Molecular mechanisms of pharmacological action

Bin Zhao, Xiang Wang, Xiaolong Wang, Song Tang, Jie Mao. Research progress on the antitumour mechanism of α-Mangostin[J]. Chinese Archives of General Surgery(Electronic Edition), 2019, 13(02): 157-160.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2019.02.016

https://zhptwkxwx.cma-cmc.com.cn/EN/Y2019/V13/I02/157

References 29

[1]	Chen G,Li Y,Wang W, et al. Bioactivity and pharmacological properties of α-mangostin from the mangosteen fruit: a review[J]. Expert Opin Ther Pat, 2018, 28(5): 415-427.
[2]	Yates P,Stout GH. The structure of mangostin[J]. Chem Communications, 1968, 4(4): 211-212.
[3]	Xia Y,Li Y,Westover KD, et al. Inhibition of cell proliferation in an NRAS mutant melanoma cell Line by combining Sorafenib and α-Mangostin[J]. PLoS One, 2016, 11(5): e0155217.
[4]	Kwak HH,Kim IR,Kim HJ, et al. α-Mangostin induces ppoptosis and cell cycle arrest in oral squamous cell carcinoma cell[J]. Evid Based Complement Alternat Med, 2016, 2016: 5352412.
[5]	Wang F,Ma H,Liu Z, et al. α-Mangostin inhibits DMBA/TPA-induced skin cancer through inhibiting inflammation and promoting autophagy and apoptosis by regulating PI3K/Akt/mTOR signaling pathway in mice[J]. Biomed Pharmacother, 2017, 92: 672-680.
[6]	毛燕. 苦参碱对宫颈癌细胞JAK-STAT信号传导通路的负调控机制研究[D]. 兰州: 甘肃中医药大学, 2015.
[7]	郭林丰,童姗姗,余江南, 等. 苦参碱抗肿瘤作用机制研究进展[J]. 中国中药杂志, 2013, 38(20): 3409-3412.
[8]	Watanapokasin R,Jarinthanan F,Nakamura Y, et al. Effects of α-mangostin on apoptosis induction of human colon cancer[J]. World J Gastroenterol, 2011, 17(16): 2086-2095.
[9]	Park SJ,Park BS,Yu SB, et al. Induction of apoptosis and inhibition of epithelial mesenchymal transition by α-Mangostin in MG-63 cell lines[J]. Evid Based Complement Alternat Med, 2018, 2018: 3985082.
[10]	Kumazaki M,Noguchi S,Yasui Y, et al. Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells[J]. J Nutr Biochem, 2013, 24(11): 1849-1858.
[11]	Krajarng A,Nakamura Y,Suksamrarn S, et al. α-Mangostin induces apoptosis in human chondrosarcoma cells through downregulation of ERK/JNK and Akt signaling pathway[J]. J Agric Food Chem, 2011, 59(10): 5746-5754.
[12]	Li G,Petiwala SM,Nonn L, et al. Inhibition of CHOP accentuates the apoptotic effect of α-mangostin from the mangosteen fruit (Garcinia mangostana) in 22Rv1 prostate cancer cells[J]. Biochem Biophys Res Commun, 2014, 453(1): 75-80.
[13]	Kaomongkolgit R. Alpha-mangostin suppresses MMP-2 and MMP-9 expression in head and neck squamous carcinoma cells[J]. Odontology, 2013, 101(2): 227-232.
[14]	Yuan J,Wu Y,Lu G. α-Mangostin suppresses lipopolysaccharide-induced invasion by inhibiting matrix metalloproteinase-2/9 and increasing E-cadherin expression through extracellular signal-regulated kinase signaling in pancreatic cancer cells[J]. Oncol Lett, 2013, 5(6): 1958-1964.
[15]	Xu Q,Ma J,Lei J, et al. α-Mangostin suppresses the viability and epithelial-mesenchymal transition of pancreatic cancer cells by downregulating the PI3K/Akt pathway[J]. Biomed Res Int, 2014, 2014: 546353.
[16]	Sovannarith K,HoChang J,OkSeon K, et al. α-Mangostin induces G1 cell cycle arrest in HCT116 cells through p38MAPK-p16INK4a pathway[J]. Rsc Advances, 2015, 5(44): 34752-34760
[17]	吴孟晏,胡新荣. eIF4E在肿瘤转移中的作用[J]. 实用癌症杂志, 2012, 27(1): 83-85.
[18]	Jittiporn K,Suwanpradid J,Patel C, et al. Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin[J]. Microvasc Res, 2014, 93: 72-79.
[19]	Arifianti L,Sukardima N,Rofida S, et al. Antiangiogenesis from pericarp of mangosteen on t47d breast cancer[J]. E-Journal Planta Husada, 2014, 2(1): 12-15.
[20]	马林伟,徐红涛,戴小丽, 等. α-倒捻子素对MKN45胃癌细胞增殖、迁移、侵袭和血管生成的影响及其作用机制[J]. 重庆医科大学学报, 2017, 42(11): 1426-1432.
[21]	Hafeez BB,Mustafa A,Fischer JW, et al. α-Mangostin: A dietary antioxidant derived from the pericarp of Garcinia mangostana L. inhibits pancreatic tumor growth in xenograft mouse model[J]. Antioxid Redox Signal, 2014, 21(5): 682-699.
[22]	范悦,王世明,石青青. 苦参碱对肝癌细胞增殖及其细胞自噬的影响[J]. 中国当代医药, 2013, 20(7): 11-13.
[23]	张军强. 苦参碱诱导胃癌细胞自噬和凋亡的机制研究[D]. 兰州: 兰州大学, 2013.
[24]	Assunção GC,Linden R. Programmed cell deaths. Apoptosis and alternative deathstyles[J]. Eur J Biochem, 2004, 271(9): 1638-1650.
[25]	Shi N,Clinton SK,Liu Z, et al. Strawberry phytochemicals inhibit azoxymethane/dextran sodium sulfate-induced colorectal carcinogenesis in Crj: CD-1 mice[J]. Nutrients, 2015, 7(3): 1696.
[26]	Shibata MA,Iinuma M,Morimoto J, et al. α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation[J]. BMC Med, 2011, 9: 69.
[27]	Matsumoto K,Akao Y,Yi H, et al. Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells[J]. Bioorg Med Chem, 2004, 12(22): 5799-5806.
[28]	Sánchez-Pérez Y,Morales-Bárcenas R,García-Cuellar CM, et al. The alpha-mangostin prevention on cisplatin-induced apoptotic death in LLC-PK1 cells is associated to an inhibition of ROS production and p53 induction[J]. Chem Biol Interact, 2010, 188(1): 144-150.
[29]	Tangpong J,Miriyala S,Noel T, et al. Doxorubicin-induced central nervous system toxicity and protection by xanthone derivative of Garcinia mangostana[J]. Neuroscience, 2011, 175: 292-299.

Please choose a citation manager

Content to export