Advances in the molecular mechanisms of necroptosis and its progression in organ ischemic injuries

doi:10.3877/cma.j.issn.1674-0793.2021.03.015

Abstract

Abstract:

Necroptosis has distinct cellular features that are different from apoptosis and is mediated by the kinase activity of RIPK1 and RIPK3. Necroptosis can be triggered by extracellular stimuli known to activate inflammation and cell death and its intracellular signaling pathway involves necrosome formation and kinases activation. Exploring the underlying mechanisms of Necroptosis and its roles in organ ischemic injuries will help to improve the understanding of the pathophysiology of cell death and tissue injury. Meanwhile, Necroptosis inhibition has potential to be an effective and efficient treatment strategy in the future.

Key words: Necroptosis, Cell death, Ischemic injury, Therapeutic strategy

Yaqing Zhan, Hanjin Lai, Jiantong Shen, Shihong Wen, Wenqi Huang. Advances in the molecular mechanisms of necroptosis and its progression in organ ischemic injuries[J]. Chinese Archives of General Surgery(Electronic Edition), 2021, 15(03): 224-228.

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