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Chinese Archives of General Surgery(Electronic Edition) ›› 2021, Vol. 15 ›› Issue (04): 304-308. doi: 10.3877/cma.j.issn.1674-0793.2021.04.015

• Review • Previous Articles     Next Articles

Progress of inhibitors programmed death receptor-1, PD-L1 and CTLA-4 in the treatment of advanced liver cancer

Junqi Wang1, Feng Xu1,()   

  1. 1. Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China
  • Received:2021-04-15 Online:2021-08-03 Published:2021-08-18
  • Contact: Feng Xu

Abstract:

Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Although there are relatively mature and systematic treatment regimens, the overall therapeutic effect of HCC is still unsatisfactory. In addition to tyrosine kinase inhibitors, immune checkpoint inhibitors (ICIs) have been widely used for advanced HCC patients and achieved good results. In this review, we summarize the latest progress of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), programmed death receptor-1 (PD-1) and programmed death receptor-1 ligand (PD-L1) inhibitors in the treatment of advanced HCC, aiming to guide the clinical treatment and research.

Key words: Immune checkpoint inhibitors, PD-1, PD-L1, CTLA-4, Carcinoma, hepatocellular, Immunotherapy

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