Progress of the use of esketamine in perioperative analgesia

doi:10.3877/cma.j.issn.1674-0793.2025.02.012

Abstract

Abstract:

Esketamine is a non-competitive N-methyl-D-aspartate receptor antagonist with significant analgesic effects， and has shown important advantages in the antidepressant treatment， anesthesia induction and maintenance. Compared with traditional analgesic drugs， esketamine has a unique mechanism of action， higher potency and relatively fewer side effects， and its application in perioperative analgesia has attracted more and more attention. This article reviews the analgesic mechanism of esketamine and its application in perioperative analgesia， in order to provide reference for its application in perioperative analgesia.

Key words: Esketamine, Perioperative period, Analgesia

Xiaomei Zhang, Junlin Wen, Xiaozu Liao, Xiqiang Huang, Binfei Li. Progress of the use of esketamine in perioperative analgesia[J]. Chinese Archives of General Surgery(Electronic Edition), 2025, 19(02): 130-134.

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