Progress in the pathogenesis of gastroesophageal reflux disease

doi:10.3877/cma.j.issn.1647-0793.2013.03.014

Abstract

Abstract:

Gastroesophageal reflux disease (GERD) is a condition which develops when contents of upper gastrointestinal tract reflux into the esophagus, causing injury to esophageal tissue or symptoms, such as heartburn, regurgitation, chronic cough. The pathogenesis of GERD is related with damage of the antireflux barrier, attack of the refluxate, the Helicobacter pylori(Hp) infection, reduced and dysfunction of Cajal cells and so on.

Key words: Gastroesophageal reflux disease, Etiology, Pathogenesis

Jun FANG, Xiao-jun YANG, Chun-zhao YU, Jian-ping ZHANG. Progress in the pathogenesis of gastroesophageal reflux disease[J]. Chinese Archives of General Surgery(Electronic Edition), 2013, 07(03): 217-221.

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