The study of relationship between intestinal permeability and nutritional status, immune function,and inflammation reaction in patients with gastrointestinal cancer

doi:10.3877/cma.j.issn.1674-0793.2007.03.013

Abstract

Abstract:

Objective

To study the relationship between intestinal permeability and nutritional status， immune function， and inflammatory reaction in patients with gastrointestinal cancer.

Methods

124 patients with gastrointestinalcancerweredividedinto the normalnutrition (NN），theborderlineormildmalnutrition（BMM）and the severe malnutrition（SM）groups by Nutritional Risk Index. The Lactulose/Mannitol (L/M) and the markers of nutri tional status， immune function， and inflammatory reaction were detected， and the correlations between the L/M and the markers were studied.

Results

As for SM and BMM group， the PAB and ALB，TF were lower than those in NN group. The negative linear correlations were found between L/M and ALB， TF， IgG， IgA， CD₃， CD₄ and CD₄/CD₈（P<0.01）， and also between L/M and PAB and TLC（P<0.05）， and positively between L/M and CD₈ and CRP in SM and BMM group.

Conclusion

The gut barrier impairment of patients with gastrointestinal cancer companying the severe malnutrition is worse than those companying the borderline or mild malnutrition; the degrees of impairment are negatively correlated with their own nutritional status and immune function， and positively with inflammatory reaction.

Key words: Gastrointestinal cancer, Intestinal Permeability, Nutritional Status, Immune Function, Inflammatory Reaction

Si-zeng CHEN, Hongshuang HUANG, Yong-kun Lin. The study of relationship between intestinal permeability and nutritional status, immune function,and inflammation reaction in patients with gastrointestinal cancer[J]. Chinese Archives of General Surgery(Electronic Edition), 2007, 01(03): 165-168.

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References 12

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	营养指标(g/L)			体液免疫指标
	PAB	ALB	TF	IgG	IgA	IgM
NN组(50例)	270.56±94.16	41.30±2.38	2.05±0.46	10.668±3.508	2.542±0.711	1.134±0.632
BMM组(48例)	237.92±78.28^□	34.99±2.96^☆	1.80±0.56^□	11.127±3.174	2.099±0.638^☆	1.274±0.56
SM组(26例)	147.08±53.45^*#	28.88±1.46^*#	1.56±0.47^*△	11.209±4.016	1.835±0.599^*	1.312±0.427
	细胞免疫指标					炎症指标
	TLC(g/L)	CD₃(%)	CD₄(%)	CD₈(%)	CD₄/CD₈	CRP	C₃	C₄
NN组(50例)	2.01±0.56	61.01±12.58	23.35±9.36	11.17±0.87	2.10±0.90	5.24±6.32	1.09±0.25	0.22±0.07
BMM组(48例)	1.75±0.58^□	58.52±7.35	20.07±6.00^□	11.17±1.30	1.86±0.70	12.27±7.59^□	1.07±0.33	0.26±0.15
SM组(26例)	1.48±0.54^*△	40.96±10.44^*#	15.13±6.78^*#	10.73±1.49	1.53±0.67^*	31.90±27.79^*#	1.00±0.28	0.22±0.08

	营养指标(g/L)			体液免疫指标
	PAB	ALB	TF	IgG	IgA	IgM
NN组(50例)	270.56±94.16	41.30±2.38	2.05±0.46	10.668±3.508	2.542±0.711	1.134±0.632
BMM组(48例)	237.92±78.28^□	34.99±2.96^☆	1.80±0.56^□	11.127±3.174	2.099±0.638^☆	1.274±0.56
SM组(26例)	147.08±53.45^*#	28.88±1.46^*#	1.56±0.47^*△	11.209±4.016	1.835±0.599^*	1.312±0.427
	细胞免疫指标					炎症指标
	TLC(g/L)	CD₃(%)	CD₄(%)	CD₈(%)	CD₄/CD₈	CRP	C₃	C₄
NN组(50例)	2.01±0.56	61.01±12.58	23.35±9.36	11.17±0.87	2.10±0.90	5.24±6.32	1.09±0.25	0.22±0.07
BMM组(48例)	1.75±0.58^□	58.52±7.35	20.07±6.00^□	11.17±1.30	1.86±0.70	12.27±7.59^□	1.07±0.33	0.26±0.15
SM组(26例)	1.48±0.54^*△	40.96±10.44^*#	15.13±6.78^*#	10.73±1.49	1.53±0.67^*	31.90±27.79^*#	1.00±0.28	0.22±0.08

分组（n=124）	M（μg）	L（μg）	L/M
NN组（n=50）	429.43±38.16	2.79±0.89	0.0065±0.0021
BMM组（n=48）	433.92±51.47	9.13±0.77^☆	0.0214±0.0034^☆
SM组（n=26）	437.28±46.32	10.02±0.77^☆△	0.0231±0.0026^*#

分组（n=124）	M（μg）	L（μg）	L/M
NN组（n=50）	429.43±38.16	2.79±0.89	0.0065±0.0021
BMM组（n=48）	433.92±51.47	9.13±0.77^☆	0.0214±0.0034^☆
SM组（n=26）	437.28±46.32	10.02±0.77^☆△	0.0231±0.0026^*#

指标	L/M比值
	NN组(n=50)			BMM组(n=48)			SM组(n=26)
	r	R ²	P	r	R ²	P	r	R ²	P
PAB	-0.691	0.477	0.000^*	0.348	0.121	0.018^#	0.487	0.237	0.012^#
ALB	-0.773	0.598	0.000^*	-0.316	0.100	0.029^#	-0.701	0.491	0.000^*
TF	-0.747	0.558	0.000^*	-0.583	0.34	0.000^*	-0.519	0.269	0.007^*
IgG	-0.803	0.645	0.000^*	-0.535	0.286	0.000^*	-0.784	0.615	0.000^*
IgA	-0.834	0.696	0.000^*	-0.522	0.272	0.000^*	-0.732	0.536	0.000^*
IgM	0.003	0.000	0.983	-0.273	0.075	0.060	0.366	0.134	0.066
TLC	-0.688	0.473	0.000^*	-0.49	0.240	0.000^*	-0.452	0.204	0.020^#
CD₃	-0.821	0.674	0.000^*	-0.31	0.096	0.032^#	-0.745	0.555	0.000^*
CD₄	-0.791	0.626	0.000^*	-0.53	0.281	0.000^*	-0.715	0.511	0.000^*
CD₈	0.609	0.371	0.000^*	0.607	0.368	0.000^*	0.511	0.261	0.008^*
CD₄/CD₈	-0.817	0.667	0.000^*	-0.444	0.197	0.002^*	-0.806	0.65	0.000^*
CRP	0.746	0.557	0.000^*	0.553	0.306	0.000^*	0.723	0.523	0.000^*
C3	0.071	0.005	0.623	-0.105	0.011	0.479	-0.128	0.016	0.533
C4	0.119	0.014	0.412-	-0.084	0.007	0.570-	-0.079	0.006	0.700

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