Abstract:

Objective

To compare clinical results of surgical resection(SR)and radiofrequency ablation(RFA)for small primary liver carcinoma (≤5 cm).

Methods

Eighty-eight patients received surgical resection(42 cases)and radiofrequency ablation (46 cases),and the long-time results were analyzed.

Results

With mean follow-up time 34.36 (6-72)months,the 1,3,5-year disease free survival rates in SR and RFA group were 85.4%,40.9%,29.2%vs 82.6%,27.7%,16.4%,the mean disease free survival time were 32.78 vs 29.39 months (P=0.51).When the tumor diameter≤3 cm, the 1,3,5-year disease free survival rates in SR and RFA group were 85.7%,62.5%,37.5%vs 85.0%,37.4%,29.9%(P=0.50).when the tumor diameter in 3-5 cm,The 1,3,5-year disease free survival rates in SR and RFA group were 85.7%,30.6%,30.0%vs 80.8%,21.8%,10.9%(P=0.58).The 1,3,5-year cumulative survival rates in SR and RFA group were 100%,63.7%,50.4%vs 100%,66.3%,37.4%,the mean cumulative survival time were 50.78 vs 47.62 months(P=0.67).When the tumor diameter≤3 cm,The 1,3,5-year cumulative survival rates in SR and RFA group were 100%,78.8%,59.1%vs 100%,78.8%,51.7%(P=0.87).When the tumor diameter in 3-5 cm,the 1,3,5-year cumulative survival rates in SR and RFA group were 100%,56.8%,45.4%vs 100%,56.9%,29.1%(P=0.41).After balance the multiple factors'effect,Cox results showed the difference of disease free survival rates and cumulative survival rates between SR and RFA was statistically not significant,but the tumor number was significantly effect the survival time (P=0.02).

Conclusion

Radiofreqency ablation is a safe and satisfactory treatment for small liver carcinoma(≤5 cm)with short and long-time results that similar to surgicalresection,which can be selected to smallliver carcinoma as one of the first-line treatments.

Key words: Primarylivercarcinoma, SurgicalProcedures, Radiofrequencyablation