Abstract:
Objective
To evaluate the clinical effects of hyperthermic intraperitoneal chemotherapy(HIPEC) combined with venous chemotherapy for the treatment of advanced colon cancer.
Methods
Eighty-nine cases of advanced colon cancer were randomly divided into experiment group (44 cases)and control group(45 cases).One week after radical colonectomy,HIPEC was used four times,then the FOLFOX6 chemotherapy plan was carried out monthly for six months in experiment group. Whereas the control group was received FOLFOX6 chemotherapy plan monthly for six months only.The postoperative survival rate(1-,3-and 5-year)and KPS scores of patients were compared between the two groups.
Results
There were no severe complications occurred in two groups.KPS scale increasing rate was 53.65%in experiment group and 40.00%in control group respectively(P＜0.05).The 1-,3-and 5-year survival rates in treatment group were 96.8%,72.3%，52.3%and 95.7%,65.4%,43.0%in control group respectively.The 3-and 5-year survival rates achieved statistical significance between the two groups (P ＜0.05).
Conclusion
Combined with venous chemotherapy, HIPEC can improve the prognosis and raise survivalrate of the advanced colon cancer patients significantly.
Key words:
Coloncancer,
Cancerchemotherapy,
Regionalperfusion,
Prognosis
Xiao-dong GUAN, Jian LI, Ying-bin JIA, Yong-hui SU, Hong-cheng ZHONG. Hyperthermic intraperitoneal chemotherapy combined with venous chemotherapy for advanced colon cancer[J]. Chinese Archives of General Surgery(Electronic Edition), 2009, 03(03): 223-226.