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Chinese Archives of General Surgery(Electronic Edition) ›› 2009, Vol. 03 ›› Issue (03): 223-226. doi: 10.3877/cma.j.issn.1674-0793.2009.03.013

• Original Articles • Previous Articles     Next Articles

Hyperthermic intraperitoneal chemotherapy combined with venous chemotherapy for advanced colon cancer

Xiao-dong GUAN1,(), Jian LI1, Ying-bin JIA1, Yong-hui SU1, Hong-cheng ZHONG1   

  1. 1.Department of General Surgery Ⅲ,the Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai 519000,China
  • Received:2009-04-07 Online:2009-06-01 Published:2024-11-30
  • Contact: Xiao-dong GUAN

Abstract:

Objective

To evaluate the clinical effects of hyperthermic intraperitoneal chemotherapy(HIPEC) combined with venous chemotherapy for the treatment of advanced colon cancer.

Methods

Eighty-nine cases of advanced colon cancer were randomly divided into experiment group (44 cases)and control group(45 cases).One week after radical colonectomy,HIPEC was used four times,then the FOLFOX6 chemotherapy plan was carried out monthly for six months in experiment group. Whereas the control group was received FOLFOX6 chemotherapy plan monthly for six months only.The postoperative survival rate(1-,3-and 5-year)and KPS scores of patients were compared between the two groups.

Results

There were no severe complications occurred in two groups.KPS scale increasing rate was 53.65%in experiment group and 40.00%in control group respectively(P<0.05).The 1-,3-and 5-year survival rates in treatment group were 96.8%,72.3%,52.3%and 95.7%,65.4%,43.0%in control group respectively.The 3-and 5-year survival rates achieved statistical significance between the two groups (P <0.05).

Conclusion

Combined with venous chemotherapy, HIPEC can improve the prognosis and raise survivalrate of the advanced colon cancer patients significantly.

Key words: Coloncancer, Cancerchemotherapy, Regionalperfusion, Prognosis

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