Roles and mechanism of long non-coding RNA breast cancer anti-estrogen resistance 4 in common tumor development

doi:10.3877/cma.j.issn.1674-0793.2025.03.011

Abstract

Abstract:

Long non-coding RNA breast cancer anti-estrogen resistance 4 （lncRNA BCAR4） was found in the anti-estrogen resistance of breast cancer tumor cells for the first time.It has been identified with abnormal expression in various types of cancer， which is closely associated with tumor progression and drug resistance.Although its role in tumor development is widely recognized， the detailed molecular mechanisms remain to be further explored.This review analyzes the expression patterns of BCAR4 in a variety of cancers including breast cancer， liver cancer， colorectal cancer， lung cancer， esophageal cancer， and bladder cancer，and its impact on tumor biology， providing a comprehensive perspective on its role in tumor progression， and offering theoretical basis for future research directions and clinical applications.

Key words: Long non-coding RNA, Breast cancer anti-estrogen resistance 4, Carcinogenesis, Mechanism

Ning An, Jian Chen, Jingwei Zhang, Yiqing Xi. Roles and mechanism of long non-coding RNA breast cancer anti-estrogen resistance 4 in common tumor development[J]. Chinese Archives of General Surgery(Electronic Edition), 2025, 19(03): 203-208.

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URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2025.03.011

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References 39

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