Application of posthepatectomy enteral nutrition with cholic acid in cirrhotic rats

doi:10.3877/cma.j.issn.1674-0793.2009.03.008

Abstract

Abstract:

Objective

To explore the application of posthepatectomy enteral nutrition (EN)with cholic acid in cirrhotic rats.

Methods

Six normal rats severed as normal group, twenty-four rats with liver cirrhosis were randomly divided into pre-operation group(n=6),post-operation 1 day group(n=6),post-operation EN without cholic acid 5 day group (n=6),post-operation EN with cholic acid 5 day group (n=6).Liver function,inflammatory responses,lipid peroxidation,expression of ALB mRNA in the liver tissue,expression of liver Ki67 protein were detected.

Results

Compared with the EN without cholic acid 5 day group,serum AST,ALT and ALP were lower(P＜0.05), serum ALB and IGF-1 were higher (P＜0.05), serum IFN-γ, TNF-α and MDA content were lower(P＜0.05),serum SOD was higher (P＜0.05),expression of ALB mRNA in the liver tissue was higher (P＜0.05),expression of liver Ki67 protein was higher(P＜0.05)in the EN with cholic acid 5 day group.

Conclusion

Posthepatectomy enteral nutrition with cholic acid in cirrhotic rats can speed up liver function recovery,reduce inflammatory responses and lipid peroxidation damage,promote liver protein synthesis and liver regeneration.

Key words: Livercirrhosis, Hepatectomy, Enteralnutrition;Cholicacid

Shi-min LUO, Weimin TAN, Jian-wei LUO, Ying-zhi CHANG. Application of posthepatectomy enteral nutrition with cholic acid in cirrhotic rats[J]. Chinese Archives of General Surgery(Electronic Edition), 2009, 03(03): 204-207.

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URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2009.03.008

https://zhptwkxwx.cma-cmc.com.cn/EN/Y2009/V03/I03/204

Figures/Tables 2

References 9

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组别	AST（U/L）	ALT（U/L）	ALP（U/L）	TBIL（μmol/L）	ALB（g/L）	IGF-1（μg/L）
A	156±35	82±15	169±36	9.8±1.2	36.0±0.6	7219±161
B	272±22^*	132±10^*	274±25^*	10.3±1.4	33.8±0.3^*	6473±278^*
C	524±44^△	507±40^△	362±19^△	10.7±1.6	22.8±0.8^△	3528±216^△
D	283±21^＃	141±14^＃	291±29^＃	11.1±1.0	31.4±1.0^＃	5556±226^＃
E	246±8^＃☆	116±5^＃☆	262±6^＃☆	10.5±0.8	33.7±0.3^＃☆	6511±241^＃☆

组别	AST（U/L）	ALT（U/L）	ALP（U/L）	TBIL（μmol/L）	ALB（g/L）	IGF-1（μg/L）
A	156±35	82±15	169±36	9.8±1.2	36.0±0.6	7219±161
B	272±22^*	132±10^*	274±25^*	10.3±1.4	33.8±0.3^*	6473±278^*
C	524±44^△	507±40^△	362±19^△	10.7±1.6	22.8±0.8^△	3528±216^△
D	283±21^＃	141±14^＃	291±29^＃	11.1±1.0	31.4±1.0^＃	5556±226^＃
E	246±8^＃☆	116±5^＃☆	262±6^＃☆	10.5±0.8	33.7±0.3^＃☆	6511±241^＃☆

组别	IL-6（μg/L）	IFN-γ（μg/L）	TNF-α（μg/L）	SOD（U/L）	MDA（mmol/L）
A	13.6±2.4	13.9±2.2	13.9±1.4	189.2±6.3	6.3±1.3
B	21.3±1.9^*	27.0±2.0^*	25.5±2.9^*	165.9±5.6^*	9.5±1.4^*
C	57.6±2.4^△	76.7±3.5^△	75.2±3.6^△	128.4±4.2^△	40.4±1.9^△
D	29.5±2.2^＃	38.3±1.9^＃	38.3±1.7^＃	154.3±4.0^＃	22.9±1.9^＃
E	25.8±1.6^＃☆	32.2±2.6^＃☆	31.6±1.8^＃☆	168.1±2.6^＃☆	15.3±1.3^＃☆

组别	IL-6（μg/L）	IFN-γ（μg/L）	TNF-α（μg/L）	SOD（U/L）	MDA（mmol/L）
A	13.6±2.4	13.9±2.2	13.9±1.4	189.2±6.3	6.3±1.3
B	21.3±1.9^*	27.0±2.0^*	25.5±2.9^*	165.9±5.6^*	9.5±1.4^*
C	57.6±2.4^△	76.7±3.5^△	75.2±3.6^△	128.4±4.2^△	40.4±1.9^△
D	29.5±2.2^＃	38.3±1.9^＃	38.3±1.7^＃	154.3±4.0^＃	22.9±1.9^＃
E	25.8±1.6^＃☆	32.2±2.6^＃☆	31.6±1.8^＃☆	168.1±2.6^＃☆	15.3±1.3^＃☆

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