Abstract:
Objective
To investigate the influence of intensive insulin therapy on insulin resistance (IR)after distal radical gastrectomy.
Methods
22 gastric gancer patients were randomly divided into intensive insulin therapy group and control group (n=11),and underwent distal radical subtotal gastrectomy under epidural anesthesia. Fasting blood glucose (FBG), fasting serum insulin (FINS) and C-reactive protein（CRP）levels were assayed preoperatively and on 1st,3rd,7th day postoperatively.Insulin resistance index was calculated using homeostasis model assessment (HOMA),and the related factors were analysed by bivariate correlation method.
Results
The levels of FBG，FINS，lnHOMA-IR (P<0.05)and the incidence rate of IR were decreased significiantly in the patients underwent radical subtotal gastrectomy.The postoperative concentration of CRP of patients in intensive insulin therapy group were remarkably lower than that in control group(P<0.05).The body mass index(BMI)and FINS level were highly positively correlated with index of IR(P<0.01).
Conclusion
Compared with routine therapy,the intensive insulin therapy has more benefits to decrease insulin resistance and reduce inflammatory reaction after gastric cancer operation.
Key words:
Stomach neoplasm,
Insulin resistance,
Intensive therapy,
C-reactive protein,
Surgery
Qing-guang WANG, Yan-bing ZHOU, Shou-gen, CAO, Dong-sheng WANG, Liang LV, Shi-kuan LI. Observation of intensive insulin therapy on insulin resistance after radical gastrectomy[J]. Chinese Archives of General Surgery(Electronic Edition), 2008, 02(04): 287-290.