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Chinese Archives of General Surgery(Electronic Edition) ›› 2009, Vol. 03 ›› Issue (05): 31-33. doi: 10.3877/cma.j.issn.1674-0793.2009.05.010

• Original Articles • Previous Articles     Next Articles

Expression of topoisomerase Ⅱα in breast cancer neoadjuvant chemotherapy patients

Yuan DONG1, Yi-fan ZHU1, Song-qi LI1,()   

  1. 1.Department of Vascular Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080,China.
  • Received:2009-03-16 Online:2009-10-01 Published:2024-12-01
  • Contact: Song-qi LI

Abstract:

Objective

To investigate the relationship between the expression of topoisomerase Ⅱα in breast cancer patient and to evaluate the role of topoisomerase Ⅱα as a predictor of clinical response (CR and PR)after anthracycline-based chemotherapy for breast cancer.

Methods

forty-eight breast cancer patients receiving anthracycline-based neoadjuvant chemotherapy were restrospectively studied.Core biopsy samples before the chemotherapy and surgical samples were obtained for assay of topoisomerase Ⅱα expression.

Results

The expression of TopoⅡα decreased after chemotherapy.Overexpression of TopoⅡα before chemotherapy and the decreasing after chemotherapy was associated with better pathologic response.

Conclusions

We confirmed the predictive value of topoisomerase IIα for clinical response after anthracycline-based chemotherapy.

Key words: Breastcancer, DNAtopoisomeraseII, Neuadjuvantchemotherapy

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